Entorhinal cortex volume is associated with episodic memory related brain activation in normal aging and amnesic mild cognitive impairment
The present study examined the relationship between entorhinal cortex and hippocampal volume with fMRI activation during episodic memory function in elderly controls with no cognitive impairment and individuals with amnesic mild cognitive impairment (aMCI). Both groups displayed limited evidence for...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Springer-Verlag
2014
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| Online Access: | http://hdl.handle.net/1721.1/88493 https://orcid.org/0000-0003-1158-5692 |
| _version_ | 1826201437512663040 |
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| author | Trivedi, Mehul A. Stoub, Travis R. Murphy, Christopher M. George, Sarah deToledo-Morrell, Leyla Shah, Raj C. Gabrieli, Susan Gabrieli, John D. E. Stebbins, Glenn T. |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Trivedi, Mehul A. Stoub, Travis R. Murphy, Christopher M. George, Sarah deToledo-Morrell, Leyla Shah, Raj C. Gabrieli, Susan Gabrieli, John D. E. Stebbins, Glenn T. |
| author_sort | Trivedi, Mehul A. |
| collection | MIT |
| description | The present study examined the relationship between entorhinal cortex and hippocampal volume with fMRI activation during episodic memory function in elderly controls with no cognitive impairment and individuals with amnesic mild cognitive impairment (aMCI). Both groups displayed limited evidence for a relationship between hippocampal volume and fMRI activation. Smaller right entorhinal cortex volume was correlated with reduced activation in left and right medial frontal cortex (BA 8) during incidental encoding for both aMCI and elderly controls. However, during recognition, smaller left entorhinal cortex volume correlated with reduced activation in right BA 8 for the control group, but greater activation for the aMCI group. There was no significant relationship between entorhinal cortex volume and activation during intentional encoding in either group. The recognition-related dissociation in structure/function relationships in aMCI paralleled our behavioral findings, where individuals with aMCI displayed poorer performance relative to controls during recognition, but not encoding. Taken together, these results suggest that the relationship between entorhinal cortex volume and fMRI activation during episodic memory function is altered in individuals with aMCI. |
| first_indexed | 2024-09-23T11:51:52Z |
| format | Article |
| id | mit-1721.1/88493 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:51:52Z |
| publishDate | 2014 |
| publisher | Springer-Verlag |
| record_format | dspace |
| spelling | mit-1721.1/884932022-09-27T22:26:48Z Entorhinal cortex volume is associated with episodic memory related brain activation in normal aging and amnesic mild cognitive impairment Trivedi, Mehul A. Stoub, Travis R. Murphy, Christopher M. George, Sarah deToledo-Morrell, Leyla Shah, Raj C. Gabrieli, Susan Gabrieli, John D. E. Stebbins, Glenn T. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Gabrieli, John D. E. Gabrieli, Susan The present study examined the relationship between entorhinal cortex and hippocampal volume with fMRI activation during episodic memory function in elderly controls with no cognitive impairment and individuals with amnesic mild cognitive impairment (aMCI). Both groups displayed limited evidence for a relationship between hippocampal volume and fMRI activation. Smaller right entorhinal cortex volume was correlated with reduced activation in left and right medial frontal cortex (BA 8) during incidental encoding for both aMCI and elderly controls. However, during recognition, smaller left entorhinal cortex volume correlated with reduced activation in right BA 8 for the control group, but greater activation for the aMCI group. There was no significant relationship between entorhinal cortex volume and activation during intentional encoding in either group. The recognition-related dissociation in structure/function relationships in aMCI paralleled our behavioral findings, where individuals with aMCI displayed poorer performance relative to controls during recognition, but not encoding. Taken together, these results suggest that the relationship between entorhinal cortex volume and fMRI activation during episodic memory function is altered in individuals with aMCI. Illinois. Department of Public Health National Institute on Aging (Grant P01 AG09466) National Institute on Aging (Grant P30 AG10161) National Institute on Aging (Grant R01 AG017917) National Institute on Aging (Grant T32 AG000257) 2014-07-24T19:27:47Z 2014-07-24T19:27:47Z 2011-02 Article http://purl.org/eprint/type/JournalArticle 1931-7557 1931-7565 http://hdl.handle.net/1721.1/88493 Trivedi, Mehul A., Travis R. Stoub, Christopher M. Murphy, Sarah George, Leyla deToledo-Morrell, Raj C. Shah, Susan Whitfield-Gabrieli, John D. E. Gabrieli, and Glenn T. Stebbins. “Entorhinal Cortex Volume Is Associated with Episodic Memory Related Brain Activation in Normal Aging and Amnesic Mild Cognitive Impairment.” Brain Imaging and Behavior 5, no. 2 (June 2011): 126–136. https://orcid.org/0000-0003-1158-5692 en_US http://dx.doi.org/10.1007/s11682-011-9117-4 Brain Imaging and Behavior Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Springer-Verlag PMC |
| spellingShingle | Trivedi, Mehul A. Stoub, Travis R. Murphy, Christopher M. George, Sarah deToledo-Morrell, Leyla Shah, Raj C. Gabrieli, Susan Gabrieli, John D. E. Stebbins, Glenn T. Entorhinal cortex volume is associated with episodic memory related brain activation in normal aging and amnesic mild cognitive impairment |
| title | Entorhinal cortex volume is associated with episodic memory related brain activation in normal aging and amnesic mild cognitive impairment |
| title_full | Entorhinal cortex volume is associated with episodic memory related brain activation in normal aging and amnesic mild cognitive impairment |
| title_fullStr | Entorhinal cortex volume is associated with episodic memory related brain activation in normal aging and amnesic mild cognitive impairment |
| title_full_unstemmed | Entorhinal cortex volume is associated with episodic memory related brain activation in normal aging and amnesic mild cognitive impairment |
| title_short | Entorhinal cortex volume is associated with episodic memory related brain activation in normal aging and amnesic mild cognitive impairment |
| title_sort | entorhinal cortex volume is associated with episodic memory related brain activation in normal aging and amnesic mild cognitive impairment |
| url | http://hdl.handle.net/1721.1/88493 https://orcid.org/0000-0003-1158-5692 |
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