Cell Microenvironment Engineering and Monitoring for Tissue Engineering and Regenerative Medicine: The Recent Advances
In tissue engineering and regenerative medicine, the conditions in the immediate vicinity of the cells have a direct effect on cells’ behaviour and subsequently on clinical outcomes. Physical, chemical, and biological control of cell microenvironment are of crucial importance for the ability to dire...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2014
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| Online Access: | http://hdl.handle.net/1721.1/88527 |
| _version_ | 1826198376134213632 |
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| author | Barthes, Julien Ozcelik, Hayriye Hindie, Mathilde Ndreu-Halili, Albana Hasan, Anwarul Vrana, Nihal Engin |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Barthes, Julien Ozcelik, Hayriye Hindie, Mathilde Ndreu-Halili, Albana Hasan, Anwarul Vrana, Nihal Engin |
| author_sort | Barthes, Julien |
| collection | MIT |
| description | In tissue engineering and regenerative medicine, the conditions in the immediate vicinity of the cells have a direct effect on cells’ behaviour and subsequently on clinical outcomes. Physical, chemical, and biological control of cell microenvironment are of crucial importance for the ability to direct and control cell behaviour in 3-dimensional tissue engineering scaffolds spatially and temporally. In this review, we will focus on the different aspects of cell microenvironment such as surface micro-, nanotopography, extracellular matrix composition and distribution, controlled release of soluble factors, and mechanical stress/strain conditions and how these aspects and their interactions can be used to achieve a higher degree of control over cellular activities. The effect of these parameters on the cellular behaviour within tissue engineering context is discussed and how these parameters are used to develop engineered tissues is elaborated. Also, recent techniques developed for the monitoring of the cell microenvironment in vitro and in vivo are reviewed, together with recent tissue engineering applications where the control of cell microenvironment has been exploited. Cell microenvironment engineering and monitoring are crucial parts of tissue engineering efforts and systems which utilize different components of the cell microenvironment simultaneously can provide more functional engineered tissues in the near future. |
| first_indexed | 2024-09-23T11:03:54Z |
| format | Article |
| id | mit-1721.1/88527 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:03:54Z |
| publishDate | 2014 |
| publisher | Hindawi Publishing Corporation |
| record_format | dspace |
| spelling | mit-1721.1/885272022-09-27T16:53:40Z Cell Microenvironment Engineering and Monitoring for Tissue Engineering and Regenerative Medicine: The Recent Advances Barthes, Julien Ozcelik, Hayriye Hindie, Mathilde Ndreu-Halili, Albana Hasan, Anwarul Vrana, Nihal Engin Harvard University--MIT Division of Health Sciences and Technology Hasan, Anwarul In tissue engineering and regenerative medicine, the conditions in the immediate vicinity of the cells have a direct effect on cells’ behaviour and subsequently on clinical outcomes. Physical, chemical, and biological control of cell microenvironment are of crucial importance for the ability to direct and control cell behaviour in 3-dimensional tissue engineering scaffolds spatially and temporally. In this review, we will focus on the different aspects of cell microenvironment such as surface micro-, nanotopography, extracellular matrix composition and distribution, controlled release of soluble factors, and mechanical stress/strain conditions and how these aspects and their interactions can be used to achieve a higher degree of control over cellular activities. The effect of these parameters on the cellular behaviour within tissue engineering context is discussed and how these parameters are used to develop engineered tissues is elaborated. Also, recent techniques developed for the monitoring of the cell microenvironment in vitro and in vivo are reviewed, together with recent tissue engineering applications where the control of cell microenvironment has been exploited. Cell microenvironment engineering and monitoring are crucial parts of tissue engineering efforts and systems which utilize different components of the cell microenvironment simultaneously can provide more functional engineered tissues in the near future. 2014-07-30T14:11:34Z 2014-07-30T14:11:34Z 2014-07 2014-04 2014-07-23T09:46:36Z Article http://purl.org/eprint/type/JournalArticle 2314-6133 2314-6141 http://hdl.handle.net/1721.1/88527 Barthes, Julien, Hayriye Ozcelik, Mathilde Hindie, Albana, Ndreu-Halili, Anwarul Hasan, Nihal Engin Vrana. Cell Microenvironment Engineering and Monitoring for Tissue Engineering and Regenerative Medicine: The Recent Advances. BioMed Research International, Volume 2014 (2014), Article ID 921905, 18 pages en http://dx.doi.org/10.1155/2014/921905 BioMed Research International Creative Commons Attribution http://creativecommons.org/licenses/by/2.0 Copyright © 2014 Julien Barthes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. application/pdf Hindawi Publishing Corporation Hindawi Publishing Corporation |
| spellingShingle | Barthes, Julien Ozcelik, Hayriye Hindie, Mathilde Ndreu-Halili, Albana Hasan, Anwarul Vrana, Nihal Engin Cell Microenvironment Engineering and Monitoring for Tissue Engineering and Regenerative Medicine: The Recent Advances |
| title | Cell Microenvironment Engineering and Monitoring for Tissue Engineering and Regenerative Medicine: The Recent Advances |
| title_full | Cell Microenvironment Engineering and Monitoring for Tissue Engineering and Regenerative Medicine: The Recent Advances |
| title_fullStr | Cell Microenvironment Engineering and Monitoring for Tissue Engineering and Regenerative Medicine: The Recent Advances |
| title_full_unstemmed | Cell Microenvironment Engineering and Monitoring for Tissue Engineering and Regenerative Medicine: The Recent Advances |
| title_short | Cell Microenvironment Engineering and Monitoring for Tissue Engineering and Regenerative Medicine: The Recent Advances |
| title_sort | cell microenvironment engineering and monitoring for tissue engineering and regenerative medicine the recent advances |
| url | http://hdl.handle.net/1721.1/88527 |
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