p53 null Fluorescent Yellow Direct Repeat (FYDR) mice have normal levels of homologous recombination
The tumor suppressor p53 is a transcription factor whose function is critical for maintaining genomic stability in mammalian cells. In response to DNA damage, p53 initiates a signaling cascade that results in cell cycle arrest, DNA repair or, if the damage is severe, programmed cell death. In additi...
Main Authors: | Wiktor-Brown, Dominika M., Sukup-Jackson, Michelle R., Fakhraldeen, Saja A., Hendricks, Carrie A., Engelward, Bevin P. |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Biological Engineering |
Format: | Article |
Language: | en_US |
Published: |
Elsevier B.V.
2014
|
Online Access: | http://hdl.handle.net/1721.1/88709 |
Similar Items
-
Mitotic homologous recombination at engineered repeats in S. cerevisiae and in novel transgenic mice
by: Hendricks, Carrie A. (Carrie Anne), 1975-
Published: (2006) -
Fluorescent detection of homologous recombination reveals the impact of genetic, physiological, and environmental factors on genomic stability
by: Sukup Jackson, Michelle R
Published: (2013) -
The impact of age, exposure and genetics on homologous recombination at the engineered repeat sequence in mice
by: Wiktor-Brown, Dominika M
Published: (2008) -
Rosa26-GFP Direct Repeat (RaDR-GFP) Mice Reveal Tissue- and Age-Dependence of Homologous Recombination in Mammals In Vivo
by: Sukup-Jackson, Michelle R., et al.
Published: (2014) -
P53 gene targeting by homologous recombination in fish ES cells
by: Yan, Yan, et al.
Published: (2013)