Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids
A broad scientific community is involved in investigations aimed at delineating the mechanisms of formation and cellular processing of oxidatively generated damage to nucleic acids. Perhaps as a consequence of this breadth of research expertise, there are nomenclature problems for several of the oxi...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Informa UK (Informa Healthcare)
2014
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| Online Access: | http://hdl.handle.net/1721.1/88780 https://orcid.org/0000-0003-0011-3067 |
| _version_ | 1811069684195262464 |
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| author | Cadet, Jean Loft, Steffen Olinski, Ryszard Evans, Mark D. Bialkowski, Karol Richard Wagner, J. Dedon, Peter C. Moller, Peter Greenberg, Marc M. Cooke, Marcus S. |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Cadet, Jean Loft, Steffen Olinski, Ryszard Evans, Mark D. Bialkowski, Karol Richard Wagner, J. Dedon, Peter C. Moller, Peter Greenberg, Marc M. Cooke, Marcus S. |
| author_sort | Cadet, Jean |
| collection | MIT |
| description | A broad scientific community is involved in investigations aimed at delineating the mechanisms of formation and cellular processing of oxidatively generated damage to nucleic acids. Perhaps as a consequence of this breadth of research expertise, there are nomenclature problems for several of the oxidized bases including 8-oxo-7,8-dihydroguanine (8-oxoGua), a ubiquitous marker of almost every type of oxidative stress in cells. Efforts to standardize the nomenclature and abbreviations of the main DNA degradation products that arise from oxidative pathways are reported. Information is also provided on the main oxidative radicals, non-radical oxygen species, one-electron agents and enzymes involved in DNA degradation pathways as well in their targets and reactivity. A brief classification of oxidatively generated damage to DNA that may involve single modifications, tandem base modifications, intrastrand and interstrand cross-links together with DNA-protein cross-links and base adducts arising from the addition of lipid peroxides breakdown products is also included. |
| first_indexed | 2024-09-23T08:14:22Z |
| format | Article |
| id | mit-1721.1/88780 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:14:22Z |
| publishDate | 2014 |
| publisher | Informa UK (Informa Healthcare) |
| record_format | dspace |
| spelling | mit-1721.1/887802022-09-23T11:49:08Z Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids Cadet, Jean Loft, Steffen Olinski, Ryszard Evans, Mark D. Bialkowski, Karol Richard Wagner, J. Dedon, Peter C. Moller, Peter Greenberg, Marc M. Cooke, Marcus S. Massachusetts Institute of Technology. Department of Biological Engineering Dedon, Peter C. A broad scientific community is involved in investigations aimed at delineating the mechanisms of formation and cellular processing of oxidatively generated damage to nucleic acids. Perhaps as a consequence of this breadth of research expertise, there are nomenclature problems for several of the oxidized bases including 8-oxo-7,8-dihydroguanine (8-oxoGua), a ubiquitous marker of almost every type of oxidative stress in cells. Efforts to standardize the nomenclature and abbreviations of the main DNA degradation products that arise from oxidative pathways are reported. Information is also provided on the main oxidative radicals, non-radical oxygen species, one-electron agents and enzymes involved in DNA degradation pathways as well in their targets and reactivity. A brief classification of oxidatively generated damage to DNA that may involve single modifications, tandem base modifications, intrastrand and interstrand cross-links together with DNA-protein cross-links and base adducts arising from the addition of lipid peroxides breakdown products is also included. 2014-08-18T18:32:16Z 2014-08-18T18:32:16Z 2012-04 Article http://purl.org/eprint/type/JournalArticle 1071-5762 1029-2470 http://hdl.handle.net/1721.1/88780 Cadet, Jean, Steffen Loft, Ryszard Olinski, Mark D. Evans, Karol Bialkowski, J. Richard Wagner, Peter C. Dedon, Peter Moller, Marc M. Greenberg, and Marcus S. Cooke. “Biologically Relevant Oxidants and Terminology, Classification and Nomenclature of Oxidatively Generated Damage to Nucleobases and 2-Deoxyribose in Nucleic Acids.” Free Radic Res 46, no. 4 (April 2012): 367–381. https://orcid.org/0000-0003-0011-3067 en_US http://dx.doi.org/10.3109/10715762.2012.659248 Free Radical Research Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Informa UK (Informa Healthcare) PMC |
| spellingShingle | Cadet, Jean Loft, Steffen Olinski, Ryszard Evans, Mark D. Bialkowski, Karol Richard Wagner, J. Dedon, Peter C. Moller, Peter Greenberg, Marc M. Cooke, Marcus S. Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids |
| title | Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids |
| title_full | Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids |
| title_fullStr | Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids |
| title_full_unstemmed | Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids |
| title_short | Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids |
| title_sort | biologically relevant oxidants and terminology classification and nomenclature of oxidatively generated damage to nucleobases and 2 deoxyribose in nucleic acids |
| url | http://hdl.handle.net/1721.1/88780 https://orcid.org/0000-0003-0011-3067 |
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