Direct observation of mammalian cell growth and size regulation
We introduce a microfluidic system for simultaneously measuring single-cell mass and cell cycle progression over multiple generations. We use this system to obtain over 1,000 h of growth data from mouse lymphoblast and pro–B-cell lymphoid cell lines. Cell lineage analysis revealed a decrease in the...
Main Authors: | Son, Sungmin, Tzur, Amit, Weng, Yaochung, Jorgensen, Paul, Kim, Jisoo, Kirschner, Marc W., Manalis, Scott R |
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Other Authors: | Massachusetts Institute of Technology. Computational and Systems Biology Program |
Format: | Article |
Language: | en_US |
Published: |
Nature Publishing Group
2014
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Online Access: | http://hdl.handle.net/1721.1/88951 https://orcid.org/0000-0001-5223-9433 |
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