Transmission and Pathogenesis of Swine-Origin 2009 A(H1N1) Influenza Viruses in Ferrets and Mice
available in PMC 2010 October 12
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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American Association for the Advancement of Science (AAAS)
2014
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| Online Access: | http://hdl.handle.net/1721.1/88974 https://orcid.org/0000-0002-1288-9965 https://orcid.org/0000-0001-9344-0205 https://orcid.org/0000-0002-2085-7840 |
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| author | Maines, Taronna R. Jayaraman, Akila Belser, Jessica A. Wadford, Debra A. Pappas, Claudia Zeng, Hui Gustin, Kortney M. Pearce, Melissa B. Viswanathan, Karthik Shriver, Zachary H. Raman, Rahul Cox, Nancy J. Sasisekharan, Ram Katz, Jacqueline M. Tumpey, Terrence M. |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Maines, Taronna R. Jayaraman, Akila Belser, Jessica A. Wadford, Debra A. Pappas, Claudia Zeng, Hui Gustin, Kortney M. Pearce, Melissa B. Viswanathan, Karthik Shriver, Zachary H. Raman, Rahul Cox, Nancy J. Sasisekharan, Ram Katz, Jacqueline M. Tumpey, Terrence M. |
| author_sort | Maines, Taronna R. |
| collection | MIT |
| description | available in PMC 2010 October 12 |
| first_indexed | 2024-09-23T13:11:17Z |
| format | Article |
| id | mit-1721.1/88974 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:11:17Z |
| publishDate | 2014 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | dspace |
| spelling | mit-1721.1/889742022-10-01T13:36:09Z Transmission and Pathogenesis of Swine-Origin 2009 A(H1N1) Influenza Viruses in Ferrets and Mice Maines, Taronna R. Jayaraman, Akila Belser, Jessica A. Wadford, Debra A. Pappas, Claudia Zeng, Hui Gustin, Kortney M. Pearce, Melissa B. Viswanathan, Karthik Shriver, Zachary H. Raman, Rahul Cox, Nancy J. Sasisekharan, Ram Katz, Jacqueline M. Tumpey, Terrence M. Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. School of Engineering Koch Institute for Integrative Cancer Research at MIT Jayaraman, Akila Viswanathan, Karthik Shriver, Zachary H. Raman, Rahul Sasisekharan, Ram available in PMC 2010 October 12 Recent reports of mild to severe influenza-like illness in humans caused by a novel swine-origin 2009 A(H1N1) influenza virus underscore the need to better understand the pathogenesis and transmission of these viruses in mammals. In this study, selected 2009 A(H1N1) influenza isolates were assessed for their ability to cause disease in mice and ferrets and compared with a contemporary seasonal H1N1 virus for their ability to transmit to naïve ferrets through respiratory droplets. In contrast to seasonal influenza H1N1 virus, 2009 A(H1N1) influenza viruses caused increased morbidity, replicated to higher titers in lung tissue, and were recovered from the intestinal tract of intranasally inoculated ferrets. The 2009 A(H1N1) influenza viruses exhibited less efficient respiratory droplet transmission in ferrets in comparison with the highly transmissible phenotype of a seasonal H1N1 virus. Transmission of the 2009 A(H1N1) influenza viruses was further corroborated by characterizing the binding specificity of the viral hemagglutinin to the sialylated glycan receptors (in the human host) by use of dose-dependent direct receptor-binding and human lung tissue–binding assays. 2014-08-22T14:55:28Z 2014-08-22T14:55:28Z 2009-07 Article http://purl.org/eprint/type/JournalArticle 0036-8075 1095-9203 http://hdl.handle.net/1721.1/88974 Maines, T. R., A. Jayaraman, J. A. Belser, D. A. Wadford, C. Pappas, H. Zeng, K. M. Gustin, et al. “Transmission and Pathogenesis of Swine-Origin 2009 A(H1N1) Influenza Viruses in Ferrets and Mice.” Science (July 2, 2009). https://orcid.org/0000-0002-1288-9965 https://orcid.org/0000-0001-9344-0205 https://orcid.org/0000-0002-2085-7840 en_US http://dx.doi.org/10.1126/science.1177238 Science Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf American Association for the Advancement of Science (AAAS) PMC |
| spellingShingle | Maines, Taronna R. Jayaraman, Akila Belser, Jessica A. Wadford, Debra A. Pappas, Claudia Zeng, Hui Gustin, Kortney M. Pearce, Melissa B. Viswanathan, Karthik Shriver, Zachary H. Raman, Rahul Cox, Nancy J. Sasisekharan, Ram Katz, Jacqueline M. Tumpey, Terrence M. Transmission and Pathogenesis of Swine-Origin 2009 A(H1N1) Influenza Viruses in Ferrets and Mice |
| title | Transmission and Pathogenesis of Swine-Origin 2009 A(H1N1) Influenza Viruses in Ferrets and Mice |
| title_full | Transmission and Pathogenesis of Swine-Origin 2009 A(H1N1) Influenza Viruses in Ferrets and Mice |
| title_fullStr | Transmission and Pathogenesis of Swine-Origin 2009 A(H1N1) Influenza Viruses in Ferrets and Mice |
| title_full_unstemmed | Transmission and Pathogenesis of Swine-Origin 2009 A(H1N1) Influenza Viruses in Ferrets and Mice |
| title_short | Transmission and Pathogenesis of Swine-Origin 2009 A(H1N1) Influenza Viruses in Ferrets and Mice |
| title_sort | transmission and pathogenesis of swine origin 2009 a h1n1 influenza viruses in ferrets and mice |
| url | http://hdl.handle.net/1721.1/88974 https://orcid.org/0000-0002-1288-9965 https://orcid.org/0000-0001-9344-0205 https://orcid.org/0000-0002-2085-7840 |
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