Balancing repair and tolerance of DNA damage caused by alkylating agents
Alkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict cytotoxic DNA damage as their main mode of action, in addition to collateral mutagenic damage. Numerous cellular pathways, including direct DNA damage reversal, base excision repair (BER) and mismatch repair...
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| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2014
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| Online Access: | http://hdl.handle.net/1721.1/88982 https://orcid.org/0000-0002-7112-1454 |
| _version_ | 1826192025986269184 |
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| author | Fu, Dragony Calvo, Jennifer A. Samson, Leona D |
| author2 | Massachusetts Institute of Technology. Center for Environmental Health Sciences |
| author_facet | Massachusetts Institute of Technology. Center for Environmental Health Sciences Fu, Dragony Calvo, Jennifer A. Samson, Leona D |
| author_sort | Fu, Dragony |
| collection | MIT |
| description | Alkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict cytotoxic DNA damage as their main mode of action, in addition to collateral mutagenic damage. Numerous cellular pathways, including direct DNA damage reversal, base excision repair (BER) and mismatch repair (MMR), respond to alkylation damage to defend against alkylation-induced cell death or mutation. However, maintaining a proper balance of activity both within and between these pathways is crucial for a favourable response of an organism to alkylating agents. Furthermore, the response of an individual to alkylating agents can vary considerably from tissue to tissue and from person to person, pointing to genetic and epigenetic mechanisms that modulate alkylating agent toxicity. |
| first_indexed | 2024-09-23T09:05:10Z |
| format | Article |
| id | mit-1721.1/88982 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:05:10Z |
| publishDate | 2014 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/889822022-09-26T10:19:43Z Balancing repair and tolerance of DNA damage caused by alkylating agents Fu, Dragony Calvo, Jennifer A. Samson, Leona D Massachusetts Institute of Technology. Center for Environmental Health Sciences Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Biology Koch Institute for Integrative Cancer Research at MIT Samson, Leona D. Calvo, Jennifer A. Fu, Dragony Alkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict cytotoxic DNA damage as their main mode of action, in addition to collateral mutagenic damage. Numerous cellular pathways, including direct DNA damage reversal, base excision repair (BER) and mismatch repair (MMR), respond to alkylation damage to defend against alkylation-induced cell death or mutation. However, maintaining a proper balance of activity both within and between these pathways is crucial for a favourable response of an organism to alkylating agents. Furthermore, the response of an individual to alkylating agents can vary considerably from tissue to tissue and from person to person, pointing to genetic and epigenetic mechanisms that modulate alkylating agent toxicity. 2014-08-22T15:57:34Z 2014-08-22T15:57:34Z 2012-01 Article http://purl.org/eprint/type/JournalArticle 1474-175X 1474-1768 http://hdl.handle.net/1721.1/88982 Fu, Dragony, Jennifer A. Calvo, and Leona D. Samson. “Balancing Repair and Tolerance of DNA Damage Caused by Alkylating Agents.” Nature Reviews Cancer (January 12, 2012). https://orcid.org/0000-0002-7112-1454 en_US http://dx.doi.org/10.1038/nrc3185 Nature Reviews Cancer Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Nature Publishing Group PMC |
| spellingShingle | Fu, Dragony Calvo, Jennifer A. Samson, Leona D Balancing repair and tolerance of DNA damage caused by alkylating agents |
| title | Balancing repair and tolerance of DNA damage caused by alkylating agents |
| title_full | Balancing repair and tolerance of DNA damage caused by alkylating agents |
| title_fullStr | Balancing repair and tolerance of DNA damage caused by alkylating agents |
| title_full_unstemmed | Balancing repair and tolerance of DNA damage caused by alkylating agents |
| title_short | Balancing repair and tolerance of DNA damage caused by alkylating agents |
| title_sort | balancing repair and tolerance of dna damage caused by alkylating agents |
| url | http://hdl.handle.net/1721.1/88982 https://orcid.org/0000-0002-7112-1454 |
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