Balancing repair and tolerance of DNA damage caused by alkylating agents

Balancing repair and tolerance of DNA damage caused by alkylating agents

Alkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict cytotoxic DNA damage as their main mode of action, in addition to collateral mutagenic damage. Numerous cellular pathways, including direct DNA damage reversal, base excision repair (BER) and mismatch repair...

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Bibliographic Details
Main Authors:	Fu, Dragony, Calvo, Jennifer A., Samson, Leona D
Other Authors:	Massachusetts Institute of Technology. Center for Environmental Health Sciences
Format:	Article
Language:	en_US
Published:	Nature Publishing Group 2014
Online Access:	http://hdl.handle.net/1721.1/88982 https://orcid.org/0000-0002-7112-1454

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