Heparin and Heparan Sulfate: Analyzing Structure and Microheterogeneity [chapter]
available in PMC 2013 August 28
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Springer-Verlag Berlin Heidelberg
2014
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| Online Access: | http://hdl.handle.net/1721.1/88991 https://orcid.org/0000-0001-9344-0205 https://orcid.org/0000-0002-2085-7840 |
| _version_ | 1826202163065389056 |
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| author | Shriver, Zachary H. Capila, Ishan Venkataraman, Ganesh Sasisekharan, Ram |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Shriver, Zachary H. Capila, Ishan Venkataraman, Ganesh Sasisekharan, Ram |
| author_sort | Shriver, Zachary H. |
| collection | MIT |
| description | available in PMC 2013 August 28 |
| first_indexed | 2024-09-23T12:03:29Z |
| format | Article |
| id | mit-1721.1/88991 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T12:03:29Z |
| publishDate | 2014 |
| publisher | Springer-Verlag Berlin Heidelberg |
| record_format | dspace |
| spelling | mit-1721.1/889912022-10-01T07:51:12Z Heparin and Heparan Sulfate: Analyzing Structure and Microheterogeneity [chapter] Shriver, Zachary H. Capila, Ishan Venkataraman, Ganesh Sasisekharan, Ram Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Biological Engineering Koch Institute for Integrative Cancer Research at MIT Shriver, Zachary H. Sasisekharan, Ram available in PMC 2013 August 28 The structural microheterogeneity of heparin and heparan sulfate is one of the major reasons for the multifunctionality exhibited by this class of molecules. In a physiological context, these molecules primarily exert their effects extracellularly by mediating key processes of cellular cross-talk and signaling leading to the modulation of a number of different biological activities including development, cell proliferation, and inflammation. This structural diversity is biosynthetically imprinted in a nontemplate-driven manner and may also be dynamically remodeled as cellular function changes. Understanding the structural information encoded in these molecules forms the basis for attempting to understand the complex biology they mediate. This chapter provides an overview of the origin of the structural microheterogeneity observed in heparin and heparan sulfate, and the orthogonal analytical methodologies that are required to help decipher this information. 2014-08-22T17:02:25Z 2014-08-22T17:02:25Z 2012 Article http://purl.org/eprint/type/JournalArticle 978-3-642-23055-4 978-3-642-23056-1 0171-2004 1865-0325 http://hdl.handle.net/1721.1/88991 Shriver, Zachary, Ishan Capila, Ganesh Venkataraman, and Ram Sasisekharan. “Heparin and Heparan Sulfate: Analyzing Structure and Microheterogeneity.” Chapter in Heparin: a Century of Progress. Rebecca Lever, Barbara Mulloy, and Clive P. Page (Eds). Springer-Verlag Berlin Heidelberg (December 2, 2011): 159–176. (Handbook of Experimental Pharmacology; volume 207) https://orcid.org/0000-0001-9344-0205 https://orcid.org/0000-0002-2085-7840 en_US http://dx.doi.org/10.1007/978-3-642-23056-1_8 Heparin - A Century of Progress Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Springer-Verlag Berlin Heidelberg PMC |
| spellingShingle | Shriver, Zachary H. Capila, Ishan Venkataraman, Ganesh Sasisekharan, Ram Heparin and Heparan Sulfate: Analyzing Structure and Microheterogeneity [chapter] |
| title | Heparin and Heparan Sulfate: Analyzing Structure and Microheterogeneity [chapter] |
| title_full | Heparin and Heparan Sulfate: Analyzing Structure and Microheterogeneity [chapter] |
| title_fullStr | Heparin and Heparan Sulfate: Analyzing Structure and Microheterogeneity [chapter] |
| title_full_unstemmed | Heparin and Heparan Sulfate: Analyzing Structure and Microheterogeneity [chapter] |
| title_short | Heparin and Heparan Sulfate: Analyzing Structure and Microheterogeneity [chapter] |
| title_sort | heparin and heparan sulfate analyzing structure and microheterogeneity chapter |
| url | http://hdl.handle.net/1721.1/88991 https://orcid.org/0000-0001-9344-0205 https://orcid.org/0000-0002-2085-7840 |
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