A Voxel-Based Monte Carlo Model of Drug Release from Bulk Eroding Nanoparticles
The use of polymeric nanoparticles as drug delivery devices is becoming increasingly prevalent in a variety of therapeutic applications. Despite their widespread clinical use, the factors influencing the release profiles of nanoparticle-encapsulated drugs are still not quantitatively understood. We...
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| Format: | Article |
| Language: | en_US |
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American Scientific Publishers
2014
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| Online Access: | http://hdl.handle.net/1721.1/89031 https://orcid.org/0000-0002-2085-7840 |
| _version_ | 1826191816129511424 |
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| author | Eavarone, David A. Soundararajan, Venkataramanan Haller, Toomas Sasisekharan, Ram |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Eavarone, David A. Soundararajan, Venkataramanan Haller, Toomas Sasisekharan, Ram |
| author_sort | Eavarone, David A. |
| collection | MIT |
| description | The use of polymeric nanoparticles as drug delivery devices is becoming increasingly prevalent in a variety of therapeutic applications. Despite their widespread clinical use, the factors influencing the release profiles of nanoparticle-encapsulated drugs are still not quantitatively understood. We present here a new, semi-empirical model of drug release from polymeric nanoparticles using a formulation of dexamethasone encapsulated within poly(lactic-co-glycolic acid) to set model parameters. We introduce a three-dimensional voxel-based framework for Monte Carlo simulations that enables direct investigation of the entire spherical nanoparticle during particle degradation and drug release. Due to implementation of this model at the nanoscale, we utilize assumptions that simplify the model while still allowing multi-phase drug release to be simulated with good correlation to experimental results. In the future, emerging mechanistic understandings of nanoparticle drug release may be integrated into this simulation framework to increase predictive power. |
| first_indexed | 2024-09-23T09:01:44Z |
| format | Article |
| id | mit-1721.1/89031 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:01:44Z |
| publishDate | 2014 |
| publisher | American Scientific Publishers |
| record_format | dspace |
| spelling | mit-1721.1/890312022-09-30T12:53:37Z A Voxel-Based Monte Carlo Model of Drug Release from Bulk Eroding Nanoparticles Eavarone, David A. Soundararajan, Venkataramanan Haller, Toomas Sasisekharan, Ram Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Biological Engineering Koch Institute for Integrative Cancer Research at MIT Eavarone, David A. Soundararajan, Venkataramanan Haller, Toomas Sasisekharan, Ram The use of polymeric nanoparticles as drug delivery devices is becoming increasingly prevalent in a variety of therapeutic applications. Despite their widespread clinical use, the factors influencing the release profiles of nanoparticle-encapsulated drugs are still not quantitatively understood. We present here a new, semi-empirical model of drug release from polymeric nanoparticles using a formulation of dexamethasone encapsulated within poly(lactic-co-glycolic acid) to set model parameters. We introduce a three-dimensional voxel-based framework for Monte Carlo simulations that enables direct investigation of the entire spherical nanoparticle during particle degradation and drug release. Due to implementation of this model at the nanoscale, we utilize assumptions that simplify the model while still allowing multi-phase drug release to be simulated with good correlation to experimental results. In the future, emerging mechanistic understandings of nanoparticle drug release may be integrated into this simulation framework to increase predictive power. National Institutes of Health (U.S.) (GM57073) 2014-08-25T17:30:27Z 2014-08-25T17:30:27Z 2010-09 Article http://purl.org/eprint/type/JournalArticle 15334880 http://hdl.handle.net/1721.1/89031 Eavarone, David A., Venkataramanan Soundararajan, Toomas Haller, and Ram Sasisekharan. “A Voxel-Based Monte Carlo Model of Drug Release from Bulk Eroding Nanoparticles.” Journal of Nanoscience and Nanotechnology 10, no. 9 (September 1, 2010): 5903–5907. https://orcid.org/0000-0002-2085-7840 en_US http://dx.doi.org/10.1166/jnn.2010.2456 Journal of Nanoscience and Nanotechnology Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf American Scientific Publishers PMC |
| spellingShingle | Eavarone, David A. Soundararajan, Venkataramanan Haller, Toomas Sasisekharan, Ram A Voxel-Based Monte Carlo Model of Drug Release from Bulk Eroding Nanoparticles |
| title | A Voxel-Based Monte Carlo Model of Drug Release from Bulk Eroding Nanoparticles |
| title_full | A Voxel-Based Monte Carlo Model of Drug Release from Bulk Eroding Nanoparticles |
| title_fullStr | A Voxel-Based Monte Carlo Model of Drug Release from Bulk Eroding Nanoparticles |
| title_full_unstemmed | A Voxel-Based Monte Carlo Model of Drug Release from Bulk Eroding Nanoparticles |
| title_short | A Voxel-Based Monte Carlo Model of Drug Release from Bulk Eroding Nanoparticles |
| title_sort | voxel based monte carlo model of drug release from bulk eroding nanoparticles |
| url | http://hdl.handle.net/1721.1/89031 https://orcid.org/0000-0002-2085-7840 |
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