Transplantation of human islets without immunosuppression
Transplantation of pancreatic islets is emerging as a successful treatment for type-1 diabetes. Its current stringent restriction to patients with critical metabolic lability is justified by the long-term need for immunosuppression and a persistent shortage of donor organs. We developed an oxygenate...
| Main Authors: | , , , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
National Academy of Sciences (U.S.)
2014
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| Online Access: | http://hdl.handle.net/1721.1/89080 https://orcid.org/0000-0001-8777-9632 |
| _version_ | 1811081931296604160 |
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| author | Colton, Clark K. Ludwig, Barbara Reichel, Andreas Steffen, Anja Zimerman, Baruch Schally, Andrew V. Block, Norman L. Ludwig, Stefan Kersting, Stephan Bonifacio, Ezio Solimena, Michele Gendler, Zohar Rotem, Avi Barkai, Uriel Bornstein, Stefan R. |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Colton, Clark K. Ludwig, Barbara Reichel, Andreas Steffen, Anja Zimerman, Baruch Schally, Andrew V. Block, Norman L. Ludwig, Stefan Kersting, Stephan Bonifacio, Ezio Solimena, Michele Gendler, Zohar Rotem, Avi Barkai, Uriel Bornstein, Stefan R. |
| author_sort | Colton, Clark K. |
| collection | MIT |
| description | Transplantation of pancreatic islets is emerging as a successful treatment for type-1 diabetes. Its current stringent restriction to patients with critical metabolic lability is justified by the long-term need for immunosuppression and a persistent shortage of donor organs. We developed an oxygenated chamber system composed of immune-isolating alginate and polymembrane covers that allows for survival and function of islets without immunosuppression. A patient with type-1 diabetes received a transplanted chamber and was followed for 10 mo. Persistent graft function in this chamber system was demonstrated, with regulated insulin secretion and preservation of islet morphology and function without any immunosuppressive therapy. This approach may allow for future widespread application of cell-based therapies. |
| first_indexed | 2024-09-23T11:54:41Z |
| format | Article |
| id | mit-1721.1/89080 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:54:41Z |
| publishDate | 2014 |
| publisher | National Academy of Sciences (U.S.) |
| record_format | dspace |
| spelling | mit-1721.1/890802022-10-01T06:53:10Z Transplantation of human islets without immunosuppression Colton, Clark K. Ludwig, Barbara Reichel, Andreas Steffen, Anja Zimerman, Baruch Schally, Andrew V. Block, Norman L. Ludwig, Stefan Kersting, Stephan Bonifacio, Ezio Solimena, Michele Gendler, Zohar Rotem, Avi Barkai, Uriel Bornstein, Stefan R. Massachusetts Institute of Technology. Department of Chemical Engineering Colton, Clark K. Transplantation of pancreatic islets is emerging as a successful treatment for type-1 diabetes. Its current stringent restriction to patients with critical metabolic lability is justified by the long-term need for immunosuppression and a persistent shortage of donor organs. We developed an oxygenated chamber system composed of immune-isolating alginate and polymembrane covers that allows for survival and function of islets without immunosuppression. A patient with type-1 diabetes received a transplanted chamber and was followed for 10 mo. Persistent graft function in this chamber system was demonstrated, with regulated insulin secretion and preservation of islet morphology and function without any immunosuppressive therapy. This approach may allow for future widespread application of cell-based therapies. 2014-08-28T14:03:22Z 2014-08-28T14:03:22Z 2013-11 2013-09 Article http://purl.org/eprint/type/JournalArticle 0027-8424 1091-6490 http://hdl.handle.net/1721.1/89080 Ludwig, B., A. Reichel, A. Steffen, B. Zimerman, A. V. Schally, N. L. Block, C. K. Colton, et al. “Transplantation of Human Islets Without Immunosuppression.” Proceedings of the National Academy of Sciences 110, no. 47 (October 28, 2013): 19054–19058. https://orcid.org/0000-0001-8777-9632 en_US http://dx.doi.org/10.1073/pnas.1317561110 Proceedings of the National Academy of Sciences Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf National Academy of Sciences (U.S.) PNAS |
| spellingShingle | Colton, Clark K. Ludwig, Barbara Reichel, Andreas Steffen, Anja Zimerman, Baruch Schally, Andrew V. Block, Norman L. Ludwig, Stefan Kersting, Stephan Bonifacio, Ezio Solimena, Michele Gendler, Zohar Rotem, Avi Barkai, Uriel Bornstein, Stefan R. Transplantation of human islets without immunosuppression |
| title | Transplantation of human islets without immunosuppression |
| title_full | Transplantation of human islets without immunosuppression |
| title_fullStr | Transplantation of human islets without immunosuppression |
| title_full_unstemmed | Transplantation of human islets without immunosuppression |
| title_short | Transplantation of human islets without immunosuppression |
| title_sort | transplantation of human islets without immunosuppression |
| url | http://hdl.handle.net/1721.1/89080 https://orcid.org/0000-0001-8777-9632 |
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