MRI of the human brain at 130 microtesla
We present in vivo images of the human brain acquired with an ultralow field MRI (ULFMRI) system operating at a magnetic field B[subscript 0] ∼ 130 μT. The system features prepolarization of the proton spins at B[subscript p] ∼ 80 mT and detection of the NMR signals with a superconducting, second-de...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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National Academy of Sciences (U.S.)
2014
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| Online Access: | http://hdl.handle.net/1721.1/89116 https://orcid.org/0000-0002-6686-0252 |
| _version_ | 1826203089160372224 |
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| author | Inglis, Ben Buckenmaier, Kai SanGiorgio, Paul Pedersen, Anders F. Nichols, Matthew Alan Clarke, John |
| author2 | Massachusetts Institute of Technology. Department of Physics |
| author_facet | Massachusetts Institute of Technology. Department of Physics Inglis, Ben Buckenmaier, Kai SanGiorgio, Paul Pedersen, Anders F. Nichols, Matthew Alan Clarke, John |
| author_sort | Inglis, Ben |
| collection | MIT |
| description | We present in vivo images of the human brain acquired with an ultralow field MRI (ULFMRI) system operating at a magnetic field B[subscript 0] ∼ 130 μT. The system features prepolarization of the proton spins at B[subscript p] ∼ 80 mT and detection of the NMR signals with a superconducting, second-derivative gradiometer inductively coupled to a superconducting quantum interference device (SQUID). We report measurements of the longitudinal relaxation time T[subscript 1] of brain tissue, blood, and scalp fat at B[subscript 0] and B[subscript p], and cerebrospinal fluid at B[subscript 0]. We use these T[subscript 1] values to construct inversion recovery sequences that we combine with Carr–Purcell–Meiboom–Gill echo trains to obtain images in which one species can be nulled and another species emphasized. In particular, we show an image in which only blood is visible. Such techniques greatly enhance the already high intrinsic T[subscript 1] contrast obtainable at ULF. We further present 2D images of T[subscript 1] and the transverse relaxation time T[subscript 2] of the brain and show that, as expected at ULF, they exhibit similar contrast. Applications of brain ULFMRI include integration with systems for magnetoencephalography. More generally, these techniques may be applicable, for example, to the imaging of tumors without the need for a contrast agent and to modalities recently demonstrated with T[subscript 1ρ] contrast imaging (T[subscript 1] in the rotating frame) at fields of 1.5 T and above. |
| first_indexed | 2024-09-23T12:31:29Z |
| format | Article |
| id | mit-1721.1/89116 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T12:31:29Z |
| publishDate | 2014 |
| publisher | National Academy of Sciences (U.S.) |
| record_format | dspace |
| spelling | mit-1721.1/891162022-09-28T08:16:19Z MRI of the human brain at 130 microtesla Inglis, Ben Buckenmaier, Kai SanGiorgio, Paul Pedersen, Anders F. Nichols, Matthew Alan Clarke, John Massachusetts Institute of Technology. Department of Physics Nichols, Matthew Alan We present in vivo images of the human brain acquired with an ultralow field MRI (ULFMRI) system operating at a magnetic field B[subscript 0] ∼ 130 μT. The system features prepolarization of the proton spins at B[subscript p] ∼ 80 mT and detection of the NMR signals with a superconducting, second-derivative gradiometer inductively coupled to a superconducting quantum interference device (SQUID). We report measurements of the longitudinal relaxation time T[subscript 1] of brain tissue, blood, and scalp fat at B[subscript 0] and B[subscript p], and cerebrospinal fluid at B[subscript 0]. We use these T[subscript 1] values to construct inversion recovery sequences that we combine with Carr–Purcell–Meiboom–Gill echo trains to obtain images in which one species can be nulled and another species emphasized. In particular, we show an image in which only blood is visible. Such techniques greatly enhance the already high intrinsic T[subscript 1] contrast obtainable at ULF. We further present 2D images of T[subscript 1] and the transverse relaxation time T[subscript 2] of the brain and show that, as expected at ULF, they exhibit similar contrast. Applications of brain ULFMRI include integration with systems for magnetoencephalography. More generally, these techniques may be applicable, for example, to the imaging of tumors without the need for a contrast agent and to modalities recently demonstrated with T[subscript 1ρ] contrast imaging (T[subscript 1] in the rotating frame) at fields of 1.5 T and above. National Institutes of Health (U.S.) (Grant 5R21CA133338) 2014-08-29T17:08:18Z 2014-08-29T17:08:18Z 2013-11 2013-08 Article http://purl.org/eprint/type/JournalArticle 0027-8424 1091-6490 http://hdl.handle.net/1721.1/89116 Inglis, B., K. Buckenmaier, P. SanGiorgio, A. F. Pedersen, M. A. Nichols, and J. Clarke. “MRI of the Human Brain at 130 Microtesla.” Proceedings of the National Academy of Sciences 110, no. 48 (November 19, 2013): 19194–19201. https://orcid.org/0000-0002-6686-0252 en_US http://dx.doi.org/10.1073/pnas.1319334110 Proceedings of the National Academy of Sciences Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf National Academy of Sciences (U.S.) PNAS |
| spellingShingle | Inglis, Ben Buckenmaier, Kai SanGiorgio, Paul Pedersen, Anders F. Nichols, Matthew Alan Clarke, John MRI of the human brain at 130 microtesla |
| title | MRI of the human brain at 130 microtesla |
| title_full | MRI of the human brain at 130 microtesla |
| title_fullStr | MRI of the human brain at 130 microtesla |
| title_full_unstemmed | MRI of the human brain at 130 microtesla |
| title_short | MRI of the human brain at 130 microtesla |
| title_sort | mri of the human brain at 130 microtesla |
| url | http://hdl.handle.net/1721.1/89116 https://orcid.org/0000-0002-6686-0252 |
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