Mucin Biopolymers As Broad-Spectrum Antiviral Agents
Mucus is a porous biopolymer matrix that coats all wet epithelia in the human body and serves as the first line of defense against many pathogenic bacteria and viruses. However, under certain conditions viruses are able to penetrate this infection barrier, which compromises the protective function o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | en_US |
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American Chemical Society (ACS)
2014
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| Online Access: | http://hdl.handle.net/1721.1/89156 https://orcid.org/0000-0001-8260-338X |
| _version_ | 1826207229174349824 |
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| author | Lieleg, Oliver Lieleg, Corinna Bloom, Jesse Buck, Christopher B. Ribbeck, Katharina |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Lieleg, Oliver Lieleg, Corinna Bloom, Jesse Buck, Christopher B. Ribbeck, Katharina |
| author_sort | Lieleg, Oliver |
| collection | MIT |
| description | Mucus is a porous biopolymer matrix that coats all wet epithelia in the human body and serves as the first line of defense against many pathogenic bacteria and viruses. However, under certain conditions viruses are able to penetrate this infection barrier, which compromises the protective function of native mucus. Here, we find that isolated porcine gastric mucin polymers, key structural components of native mucus, can protect an underlying cell layer from infection by small viruses such as human papillomavirus (HPV), Merkel cell polyomavirus (MCV), or a strain of influenza A virus. Single particle analysis of virus mobility inside the mucin barrier reveals that this shielding effect is in part based on a retardation of virus diffusion inside the biopolymer matrix. Our findings suggest that purified mucins may be used as a broad-range antiviral supplement to personal hygiene products, baby formula or lubricants to support our immune system. |
| first_indexed | 2024-09-23T13:46:03Z |
| format | Article |
| id | mit-1721.1/89156 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:46:03Z |
| publishDate | 2014 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/891562022-09-28T16:00:43Z Mucin Biopolymers As Broad-Spectrum Antiviral Agents Lieleg, Oliver Lieleg, Corinna Bloom, Jesse Buck, Christopher B. Ribbeck, Katharina Massachusetts Institute of Technology. Department of Biological Engineering Ribbeck, Katharina Lieleg, Oliver Lieleg, Corinna Mucus is a porous biopolymer matrix that coats all wet epithelia in the human body and serves as the first line of defense against many pathogenic bacteria and viruses. However, under certain conditions viruses are able to penetrate this infection barrier, which compromises the protective function of native mucus. Here, we find that isolated porcine gastric mucin polymers, key structural components of native mucus, can protect an underlying cell layer from infection by small viruses such as human papillomavirus (HPV), Merkel cell polyomavirus (MCV), or a strain of influenza A virus. Single particle analysis of virus mobility inside the mucin barrier reveals that this shielding effect is in part based on a retardation of virus diffusion inside the biopolymer matrix. Our findings suggest that purified mucins may be used as a broad-range antiviral supplement to personal hygiene products, baby formula or lubricants to support our immune system. National Institutes of Health (U.S.) (grant P30-ES002109) National Institutes of Health (U.S.) (grant P50-GM068763) German Academic Exchange Service (Postdoctoral fellowship) 2014-09-03T18:09:37Z 2014-09-03T18:09:37Z 2012-06 2012-03 Article http://purl.org/eprint/type/JournalArticle 1525-7797 1526-4602 http://hdl.handle.net/1721.1/89156 Lieleg, Oliver, Corinna Lieleg, Jesse Bloom, Christopher B. Buck, and Katharina Ribbeck. “Mucin Biopolymers As Broad-Spectrum Antiviral Agents.” Biomacromolecules 13, no. 6 (June 11, 2012): 1724–1732. https://orcid.org/0000-0001-8260-338X en_US http://dx.doi.org/10.1021/bm3001292 Biomacromolecules Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf American Chemical Society (ACS) PMC |
| spellingShingle | Lieleg, Oliver Lieleg, Corinna Bloom, Jesse Buck, Christopher B. Ribbeck, Katharina Mucin Biopolymers As Broad-Spectrum Antiviral Agents |
| title | Mucin Biopolymers As Broad-Spectrum Antiviral Agents |
| title_full | Mucin Biopolymers As Broad-Spectrum Antiviral Agents |
| title_fullStr | Mucin Biopolymers As Broad-Spectrum Antiviral Agents |
| title_full_unstemmed | Mucin Biopolymers As Broad-Spectrum Antiviral Agents |
| title_short | Mucin Biopolymers As Broad-Spectrum Antiviral Agents |
| title_sort | mucin biopolymers as broad spectrum antiviral agents |
| url | http://hdl.handle.net/1721.1/89156 https://orcid.org/0000-0001-8260-338X |
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