The Roles of Individual Mammalian Argonautes in RNA Interference In Vivo

The Roles of Individual Mammalian Argonautes in RNA Interference In Vivo

Argonaute 2 (Ago2) is the only mammalian Ago protein capable of mRNA cleavage. It has been reported that the activity of the short interfering RNA targeting coding sequence (CDS), but not 3′ untranslated region (3′UTR) of an mRNA, is solely dependent on Ago2 in vitro. These studies utilized extremel...

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Bibliographic Details
Main Authors: Ruda, Vera M., Chandwani, Rohit, Sehgal, Alfica, Akinc, Akin, Charisse, Klaus, Tarakhovsky, Alexander, Novobrantseva, Tatiana I., Kotelianski, Victor E., Bogorad, Roman
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:en_US
Published: Public Library of Science 2014
Online Access:http://hdl.handle.net/1721.1/89455

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