Adaptive design of clinical trials : understanding the barriers to adoption
Thesis: M.B.A., Massachusetts Institute of Technology, Sloan School of Management, 2014.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2014
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| Online Access: | http://hdl.handle.net/1721.1/90220 |
| _version_ | 1811097438359912448 |
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| author | Khalid, Ayesha N. (Ayesha Naz) |
| author2 | Andrew Lo. |
| author_facet | Andrew Lo. Khalid, Ayesha N. (Ayesha Naz) |
| author_sort | Khalid, Ayesha N. (Ayesha Naz) |
| collection | MIT |
| description | Thesis: M.B.A., Massachusetts Institute of Technology, Sloan School of Management, 2014. |
| first_indexed | 2024-09-23T16:59:32Z |
| format | Thesis |
| id | mit-1721.1/90220 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T16:59:32Z |
| publishDate | 2014 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/902202019-04-11T06:11:30Z Adaptive design of clinical trials : understanding the barriers to adoption Khalid, Ayesha N. (Ayesha Naz) Andrew Lo. Sloan School of Management. Sloan School of Management. Sloan School of Management. Thesis: M.B.A., Massachusetts Institute of Technology, Sloan School of Management, 2014. Cataloged from PDF version of thesis. Includes bibliographical references (pages 69-72). There is great competition for clinical research funding. This is in part due to the National Institute of Health's reduced budget to support such initiatives. It has resulted in a growing trend for clinical research to use adaptive design models to accelerate clinical trials and at the same time reduce overall cost. Although such models have existed for several years, the pace of adoption remains slow, especially for early-stage clinical research. Through a review of relevant literature and interviews with industry experts, this thesis explores the barriers that inhibit the adoption of adaptive design of clinical trials. Reasons uncovered include: a lack of novel funding mechanisms, regulatory uncertainty, logistical difficulties, overly technical communications, a lack of collaboration among stakeholders, and an inability to recruit and retain patients. Then follows a series of possible solutions - some already functioning, others possible - for each of the barriers. This research found that unless efforts are devoted to addressing these underlying barriers, the widespread adoption of adaptive designs for clinical trials will not occur. The thesis concludes with recommendations and suggestions for future research. by Ayesha N. Khalid. M.B.A. 2014-09-19T21:46:52Z 2014-09-19T21:46:52Z 2014 2014 Thesis http://hdl.handle.net/1721.1/90220 890374351 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 72 pages application/pdf Massachusetts Institute of Technology |
| spellingShingle | Sloan School of Management. Khalid, Ayesha N. (Ayesha Naz) Adaptive design of clinical trials : understanding the barriers to adoption |
| title | Adaptive design of clinical trials : understanding the barriers to adoption |
| title_full | Adaptive design of clinical trials : understanding the barriers to adoption |
| title_fullStr | Adaptive design of clinical trials : understanding the barriers to adoption |
| title_full_unstemmed | Adaptive design of clinical trials : understanding the barriers to adoption |
| title_short | Adaptive design of clinical trials : understanding the barriers to adoption |
| title_sort | adaptive design of clinical trials understanding the barriers to adoption |
| topic | Sloan School of Management. |
| url | http://hdl.handle.net/1721.1/90220 |
| work_keys_str_mv | AT khalidayeshanayeshanaz adaptivedesignofclinicaltrialsunderstandingthebarrierstoadoption |