Synthetic Biology of Antimicrobial Discovery
Antibiotic discovery has a storied history. From the discovery of penicillin by Sir Alexander Fleming to the relentless quest for antibiotics by Selman Waksman, the stories have become like folklore used to inspire future generations of scientists. However, recent discovery pipelines have run dry at...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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American Chemical Society (ACS)
2014
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| Online Access: | http://hdl.handle.net/1721.1/90318 https://orcid.org/0000-0002-9999-6690 https://orcid.org/0000-0002-4639-7248 |
| _version_ | 1826205148919103488 |
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| author | Zakeri, Bijan Lu, Timothy K. |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Zakeri, Bijan Lu, Timothy K. |
| author_sort | Zakeri, Bijan |
| collection | MIT |
| description | Antibiotic discovery has a storied history. From the discovery of penicillin by Sir Alexander Fleming to the relentless quest for antibiotics by Selman Waksman, the stories have become like folklore used to inspire future generations of scientists. However, recent discovery pipelines have run dry at a time when multidrug-resistant pathogens are on the rise. Nature has proven to be a valuable reservoir of antimicrobial agents, which are primarily produced by modularized biochemical pathways. Such modularization is well suited to remodeling by an interdisciplinary approach that spans science and engineering. Herein, we discuss the biological engineering of small molecules, peptides, and non-traditional antimicrobials and provide an overview of the growing applicability of synthetic biology to antimicrobials discovery. |
| first_indexed | 2024-09-23T13:08:30Z |
| format | Article |
| id | mit-1721.1/90318 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:08:30Z |
| publishDate | 2014 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/903182022-10-01T13:14:39Z Synthetic Biology of Antimicrobial Discovery Zakeri, Bijan Lu, Timothy K. Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Research Laboratory of Electronics Massachusetts Institute of Technology. Synthetic Biology Center Zakeri, Bijan Lu, Timothy K. Antibiotic discovery has a storied history. From the discovery of penicillin by Sir Alexander Fleming to the relentless quest for antibiotics by Selman Waksman, the stories have become like folklore used to inspire future generations of scientists. However, recent discovery pipelines have run dry at a time when multidrug-resistant pathogens are on the rise. Nature has proven to be a valuable reservoir of antimicrobial agents, which are primarily produced by modularized biochemical pathways. Such modularization is well suited to remodeling by an interdisciplinary approach that spans science and engineering. Herein, we discuss the biological engineering of small molecules, peptides, and non-traditional antimicrobials and provide an overview of the growing applicability of synthetic biology to antimicrobials discovery. United States. Office of Naval Research United States. Army Research Office United States. Defense Advanced Research Projects Agency National Science Foundation (U.S.) National Institutes of Health (U.S.) (DP2 OD008435) Ellison Medical Foundation Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies 2014-09-24T18:01:43Z 2014-09-24T18:01:43Z 2012-11 2012-09 Article http://purl.org/eprint/type/JournalArticle 2161-5063 http://hdl.handle.net/1721.1/90318 Zakeri, Bijan, and Timothy K. Lu. “Synthetic Biology of Antimicrobial Discovery.” ACS Synthetic Biology 2, no. 7 (July 19, 2013): 358–372. https://orcid.org/0000-0002-9999-6690 https://orcid.org/0000-0002-4639-7248 en_US http://dx.doi.org/10.1021/sb300101g ACS Synthetic Biology Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Chemical Society (ACS) PMC |
| spellingShingle | Zakeri, Bijan Lu, Timothy K. Synthetic Biology of Antimicrobial Discovery |
| title | Synthetic Biology of Antimicrobial Discovery |
| title_full | Synthetic Biology of Antimicrobial Discovery |
| title_fullStr | Synthetic Biology of Antimicrobial Discovery |
| title_full_unstemmed | Synthetic Biology of Antimicrobial Discovery |
| title_short | Synthetic Biology of Antimicrobial Discovery |
| title_sort | synthetic biology of antimicrobial discovery |
| url | http://hdl.handle.net/1721.1/90318 https://orcid.org/0000-0002-9999-6690 https://orcid.org/0000-0002-4639-7248 |
| work_keys_str_mv | AT zakeribijan syntheticbiologyofantimicrobialdiscovery AT lutimothyk syntheticbiologyofantimicrobialdiscovery |