Development of pattern vision following early and extended blindness
Visual plasticity peaks during early critical periods of normal visual development. Studies in animals and humans provide converging evidence that gains in visual function are minimal and deficits are most severe when visual deprivation persists beyond the critical period. Here we demonstrate visual...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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National Academy of Sciences (U.S.)
2014
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| Online Access: | http://hdl.handle.net/1721.1/90319 https://orcid.org/0000-0002-8259-7079 https://orcid.org/0000-0002-5886-9003 |
| _version_ | 1811087554371387392 |
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| author | Kalia, Amy Ashwin Lesmes, Luis Andres Dorr, Michael Gandhi, Tapan Kumar Chatterjee, Garga Ganesh, Suma Bex, Peter J. Sinha, Pawan |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Kalia, Amy Ashwin Lesmes, Luis Andres Dorr, Michael Gandhi, Tapan Kumar Chatterjee, Garga Ganesh, Suma Bex, Peter J. Sinha, Pawan |
| author_sort | Kalia, Amy Ashwin |
| collection | MIT |
| description | Visual plasticity peaks during early critical periods of normal visual development. Studies in animals and humans provide converging evidence that gains in visual function are minimal and deficits are most severe when visual deprivation persists beyond the critical period. Here we demonstrate visual development in a unique sample of patients who experienced extended early-onset blindness (beginning before 1 y of age and lasting 8–17 y) before removal of bilateral cataracts. These patients show surprising improvements in contrast sensitivity, an assay of basic spatial vision. We find that contrast sensitivity development is independent of the age of sight onset and that individual rates of improvement can exceed those exhibited by normally developing infants. These results reveal that the visual system can retain considerable plasticity, even after early blindness that extends beyond critical periods. |
| first_indexed | 2024-09-23T13:47:56Z |
| format | Article |
| id | mit-1721.1/90319 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:47:56Z |
| publishDate | 2014 |
| publisher | National Academy of Sciences (U.S.) |
| record_format | dspace |
| spelling | mit-1721.1/903192022-09-28T16:15:01Z Development of pattern vision following early and extended blindness Kalia, Amy Ashwin Lesmes, Luis Andres Dorr, Michael Gandhi, Tapan Kumar Chatterjee, Garga Ganesh, Suma Bex, Peter J. Sinha, Pawan Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Kalia, Amy Ashwin Gandhi, Tapan Kumar Chatterjee, Garga Sinha, Pawan Visual plasticity peaks during early critical periods of normal visual development. Studies in animals and humans provide converging evidence that gains in visual function are minimal and deficits are most severe when visual deprivation persists beyond the critical period. Here we demonstrate visual development in a unique sample of patients who experienced extended early-onset blindness (beginning before 1 y of age and lasting 8–17 y) before removal of bilateral cataracts. These patients show surprising improvements in contrast sensitivity, an assay of basic spatial vision. We find that contrast sensitivity development is independent of the age of sight onset and that individual rates of improvement can exceed those exhibited by normally developing infants. These results reveal that the visual system can retain considerable plasticity, even after early blindness that extends beyond critical periods. National Institutes of Health (U.S.) (Grant R01EY020517) 2014-09-24T18:15:14Z 2014-09-24T18:15:14Z 2014-01 2013-07 Article http://purl.org/eprint/type/JournalArticle 0027-8424 1091-6490 http://hdl.handle.net/1721.1/90319 Kalia, A., L. A. Lesmes, M. Dorr, T. Gandhi, G. Chatterjee, S. Ganesh, P. J. Bex, and P. Sinha. “Development of Pattern Vision Following Early and Extended Blindness.” Proceedings of the National Academy of Sciences 111, no. 5 (January 21, 2014): 2035–2039. https://orcid.org/0000-0002-8259-7079 https://orcid.org/0000-0002-5886-9003 en_US http://dx.doi.org/10.1073/pnas.1311041111 Proceedings of the National Academy of Sciences Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf National Academy of Sciences (U.S.) National Academy of Sciences (U.S.) |
| spellingShingle | Kalia, Amy Ashwin Lesmes, Luis Andres Dorr, Michael Gandhi, Tapan Kumar Chatterjee, Garga Ganesh, Suma Bex, Peter J. Sinha, Pawan Development of pattern vision following early and extended blindness |
| title | Development of pattern vision following early and extended blindness |
| title_full | Development of pattern vision following early and extended blindness |
| title_fullStr | Development of pattern vision following early and extended blindness |
| title_full_unstemmed | Development of pattern vision following early and extended blindness |
| title_short | Development of pattern vision following early and extended blindness |
| title_sort | development of pattern vision following early and extended blindness |
| url | http://hdl.handle.net/1721.1/90319 https://orcid.org/0000-0002-8259-7079 https://orcid.org/0000-0002-5886-9003 |
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