Bacteriophage-based synthetic biology for the study of infectious diseases
Since their discovery, bacteriophages have contributed enormously to our understanding of molecular biology as model systems. Furthermore, bacteriophages have provided many tools that have advanced the fields of genetic engineering and synthetic biology. Here, we discuss bacteriophage-based technolo...
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Elsevier
2014
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| Online Access: | http://hdl.handle.net/1721.1/90322 https://orcid.org/0000-0002-9999-6690 https://orcid.org/0000-0002-3083-2671 https://orcid.org/0000-0002-6397-5417 |
| _version_ | 1811095640606769152 |
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| author | Citorik, Robert James Mimee, Mark Kyle Lu, Timothy K |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Citorik, Robert James Mimee, Mark Kyle Lu, Timothy K |
| author_sort | Citorik, Robert James |
| collection | MIT |
| description | Since their discovery, bacteriophages have contributed enormously to our understanding of molecular biology as model systems. Furthermore, bacteriophages have provided many tools that have advanced the fields of genetic engineering and synthetic biology. Here, we discuss bacteriophage-based technologies and their application to the study of infectious diseases. New strategies for engineering genomes have the potential to accelerate the design of novel phages as therapies, diagnostics, and tools. Though almost a century has elapsed since their discovery, bacteriophages continue to have a major impact on modern biological sciences, especially with the growth of multidrug-resistant bacteria and interest in the microbiome. |
| first_indexed | 2024-09-23T16:22:23Z |
| format | Article |
| id | mit-1721.1/90322 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:22:23Z |
| publishDate | 2014 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/903222022-10-02T07:49:29Z Bacteriophage-based synthetic biology for the study of infectious diseases Citorik, Robert James Mimee, Mark Kyle Lu, Timothy K Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Synthetic Biology Center Citorik, Robert James Mimee, Mark K. Lu, Timothy K. Since their discovery, bacteriophages have contributed enormously to our understanding of molecular biology as model systems. Furthermore, bacteriophages have provided many tools that have advanced the fields of genetic engineering and synthetic biology. Here, we discuss bacteriophage-based technologies and their application to the study of infectious diseases. New strategies for engineering genomes have the potential to accelerate the design of novel phages as therapies, diagnostics, and tools. Though almost a century has elapsed since their discovery, bacteriophages continue to have a major impact on modern biological sciences, especially with the growth of multidrug-resistant bacteria and interest in the microbiome. National Institutes of Health (U.S.) (New Innovator Award DP2 OD008435) National Institutes of Health (U.S.) (National Centers for Systems Biology Grant P50 GM098792) United States. Defense Threat Reduction Agency (022744-001) Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies (W911NF13D0001) National Institute of General Medical Sciences (U.S.) (Interdepartmental Biotechnology Training Program 5T32 GM008334) 2014-09-24T19:01:34Z 2014-09-24T19:01:34Z 2014-06 Article http://purl.org/eprint/type/JournalArticle 13695274 http://hdl.handle.net/1721.1/90322 Citorik, Robert J, Mark Mimee, and Timothy K Lu. “Bacteriophage-Based Synthetic Biology for the Study of Infectious Diseases.” Current Opinion in Microbiology 19 (June 2014): 59–69. https://orcid.org/0000-0002-9999-6690 https://orcid.org/0000-0002-3083-2671 https://orcid.org/0000-0002-6397-5417 en_US http://dx.doi.org/10.1016/j.mib.2014.05.022 Current Opinion in Microbiology Article is available under a Creative Commons license; see publisher's site for details. http://creativecommons.org/ application/pdf Elsevier Elsevier Open Access |
| spellingShingle | Citorik, Robert James Mimee, Mark Kyle Lu, Timothy K Bacteriophage-based synthetic biology for the study of infectious diseases |
| title | Bacteriophage-based synthetic biology for the study of infectious diseases |
| title_full | Bacteriophage-based synthetic biology for the study of infectious diseases |
| title_fullStr | Bacteriophage-based synthetic biology for the study of infectious diseases |
| title_full_unstemmed | Bacteriophage-based synthetic biology for the study of infectious diseases |
| title_short | Bacteriophage-based synthetic biology for the study of infectious diseases |
| title_sort | bacteriophage based synthetic biology for the study of infectious diseases |
| url | http://hdl.handle.net/1721.1/90322 https://orcid.org/0000-0002-9999-6690 https://orcid.org/0000-0002-3083-2671 https://orcid.org/0000-0002-6397-5417 |
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