Delivery of Antibody Mimics into Mammalian Cells via Anthrax Toxin Protective Antigen
Antibody mimics have significant scientific and therapeutic utility for the disruption of protein–protein interactions inside cells; however, their delivery to the cell cytosol remains a major challenge. Here we show that protective antigen (PA), a component of anthrax toxin, efficiently transports...
Main Authors: | Liao, Xiaoli, Rabideau, Amy E., Pentelute, Bradley L. |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Chemistry |
Format: | Article |
Language: | en_US |
Published: |
WILEY-VCH Verlag GmbH & Co.
2014
|
Online Access: | http://hdl.handle.net/1721.1/90351 https://orcid.org/0000-0003-2659-7012 |
Similar Items
-
Delivery of biomolecules into mammalian cells using anthrax toxin
by: Rabideau, Amy Ellen
Published: (2016) -
Atomic structure of anthrax protective antigen pore elucidates toxin translocation
by: Jiang, Jiansen, et al.
Published: (2017) -
Translocation of Non-Canonical Polypeptides into Cells Using Protective Antigen
by: Rabideau, Amy E., et al.
Published: (2015) -
Targeting Cancer Gene Dependencies with Anthrax-Mediated Delivery of Peptide Nucleic Acids
by: Lu, Zeyu, et al.
Published: (2022) -
Targeting cancer gene dependencies with anthrax-mediated delivery of peptide nucleic acids
by: Lu, Zeyu, et al.
Published: (2021)