Splice isoform and pharmacological studies reveal that sterol depletion relocalizes -synuclein and enhances its toxicity
Synucleinopathies are neurodegenerative diseases associated with toxicity of the lipid-binding protein α-synuclein (α-syn). When expressed in yeast, α-syn associates with membranes at the endoplasmic reticulum and traffics with vesicles out to the plasma membrane. At higher levels it elicits a numbe...
| Main Authors: | , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
National Academy of Sciences (U.S.)
2014
|
| Online Access: | http://hdl.handle.net/1721.1/90354 https://orcid.org/0000-0003-1307-882X |