Selective treatment and monitoring of disseminated cancer micrometastases in vivo using dual-function, activatable immunoconjugates
Drug-resistant micrometastases that escape standard therapies often go undetected until the emergence of lethal recurrent disease. Here, we show that it is possible to treat microscopic tumors selectively using an activatable immunoconjugate. The immunoconjugate is composed of self-quenching, near-i...
Main Authors: | Spring, Bryan Q., Abu-Yousif, Adnan O., Palanisami, Akilan, Rizvi, Imran, Zheng, Xiang, Mai, Zhiming, Anbil, Sriram, Sears, R. Bryan, Mensah, Lawrence B., Goldschmidt, Ruth, Erdem, S. Sibel, Oliva, Esther, Hasan, Tayyaba |
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Other Authors: | Harvard University--MIT Division of Health Sciences and Technology |
Format: | Article |
Language: | en_US |
Published: |
National Academy of Sciences (U.S.)
2014
|
Online Access: | http://hdl.handle.net/1721.1/90355 |
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