Dopamine modulation of learning and memory in the prefrontal cortex: insights from studies in primates, rodents, and birds

In this review, we provide a brief overview over the current knowledge about the role of dopamine transmission in the prefrontal cortex during learning and memory. We discuss work in humans, monkeys, rats, and birds in order to provide a basis for comparison across species that might help identify c...

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Main Authors: Puig, M. Victoria, Rose, Jonas, Schmidt, Robert, Freund, Nadja
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:en_US
Published: Frontiers Research Foundation 2014
Online Access:http://hdl.handle.net/1721.1/90936
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author Puig, M. Victoria
Rose, Jonas
Schmidt, Robert
Freund, Nadja
author2 Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
author_facet Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Puig, M. Victoria
Rose, Jonas
Schmidt, Robert
Freund, Nadja
author_sort Puig, M. Victoria
collection MIT
description In this review, we provide a brief overview over the current knowledge about the role of dopamine transmission in the prefrontal cortex during learning and memory. We discuss work in humans, monkeys, rats, and birds in order to provide a basis for comparison across species that might help identify crucial features and constraints of the dopaminergic system in executive function. Computational models of dopamine function are introduced to provide a framework for such a comparison. We also provide a brief evolutionary perspective showing that the dopaminergic system is highly preserved across mammals. Even birds, following a largely independent evolution of higher cognitive abilities, have evolved a comparable dopaminergic system. Finally, we discuss the unique advantages and challenges of using different animal models for advancing our understanding of dopamine function in the healthy and diseased brain.
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spelling mit-1721.1/909362022-09-29T12:52:10Z Dopamine modulation of learning and memory in the prefrontal cortex: insights from studies in primates, rodents, and birds Puig, M. Victoria Rose, Jonas Schmidt, Robert Freund, Nadja Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Puig, M. Victoria Rose, Jonas In this review, we provide a brief overview over the current knowledge about the role of dopamine transmission in the prefrontal cortex during learning and memory. We discuss work in humans, monkeys, rats, and birds in order to provide a basis for comparison across species that might help identify crucial features and constraints of the dopaminergic system in executive function. Computational models of dopamine function are introduced to provide a framework for such a comparison. We also provide a brief evolutionary perspective showing that the dopaminergic system is highly preserved across mammals. Even birds, following a largely independent evolution of higher cognitive abilities, have evolved a comparable dopaminergic system. Finally, we discuss the unique advantages and challenges of using different animal models for advancing our understanding of dopamine function in the healthy and diseased brain. 2014-10-15T12:53:42Z 2014-10-15T12:53:42Z 2014-08 2014-05 Article http://purl.org/eprint/type/JournalArticle 1662-5110 http://hdl.handle.net/1721.1/90936 Puig, M. Victoria, Jonas Rose, Robert Schmidt, and Nadja Freund. “Dopamine Modulation of Learning and Memory in the Prefrontal Cortex: Insights from Studies in Primates, Rodents, and Birds.” Front. Neural Circuits. 8 (August 5, 2014). en_US http://dx.doi.org/10.3389/fncir.2014.00093 Frontiers in Neural Circuits Creative Commons Attribution http://creativecommons.org/licenses/by/4.0/ application/pdf Frontiers Research Foundation Frontiers Research Foundation
spellingShingle Puig, M. Victoria
Rose, Jonas
Schmidt, Robert
Freund, Nadja
Dopamine modulation of learning and memory in the prefrontal cortex: insights from studies in primates, rodents, and birds
title Dopamine modulation of learning and memory in the prefrontal cortex: insights from studies in primates, rodents, and birds
title_full Dopamine modulation of learning and memory in the prefrontal cortex: insights from studies in primates, rodents, and birds
title_fullStr Dopamine modulation of learning and memory in the prefrontal cortex: insights from studies in primates, rodents, and birds
title_full_unstemmed Dopamine modulation of learning and memory in the prefrontal cortex: insights from studies in primates, rodents, and birds
title_short Dopamine modulation of learning and memory in the prefrontal cortex: insights from studies in primates, rodents, and birds
title_sort dopamine modulation of learning and memory in the prefrontal cortex insights from studies in primates rodents and birds
url http://hdl.handle.net/1721.1/90936
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