Dopamine modulation of learning and memory in the prefrontal cortex: insights from studies in primates, rodents, and birds
In this review, we provide a brief overview over the current knowledge about the role of dopamine transmission in the prefrontal cortex during learning and memory. We discuss work in humans, monkeys, rats, and birds in order to provide a basis for comparison across species that might help identify c...
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Format: | Article |
Language: | en_US |
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Frontiers Research Foundation
2014
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Online Access: | http://hdl.handle.net/1721.1/90936 |
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author | Puig, M. Victoria Rose, Jonas Schmidt, Robert Freund, Nadja |
author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Puig, M. Victoria Rose, Jonas Schmidt, Robert Freund, Nadja |
author_sort | Puig, M. Victoria |
collection | MIT |
description | In this review, we provide a brief overview over the current knowledge about the role of dopamine transmission in the prefrontal cortex during learning and memory. We discuss work in humans, monkeys, rats, and birds in order to provide a basis for comparison across species that might help identify crucial features and constraints of the dopaminergic system in executive function. Computational models of dopamine function are introduced to provide a framework for such a comparison. We also provide a brief evolutionary perspective showing that the dopaminergic system is highly preserved across mammals. Even birds, following a largely independent evolution of higher cognitive abilities, have evolved a comparable dopaminergic system. Finally, we discuss the unique advantages and challenges of using different animal models for advancing our understanding of dopamine function in the healthy and diseased brain. |
first_indexed | 2024-09-23T15:07:47Z |
format | Article |
id | mit-1721.1/90936 |
institution | Massachusetts Institute of Technology |
language | en_US |
last_indexed | 2024-09-23T15:07:47Z |
publishDate | 2014 |
publisher | Frontiers Research Foundation |
record_format | dspace |
spelling | mit-1721.1/909362022-09-29T12:52:10Z Dopamine modulation of learning and memory in the prefrontal cortex: insights from studies in primates, rodents, and birds Puig, M. Victoria Rose, Jonas Schmidt, Robert Freund, Nadja Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Puig, M. Victoria Rose, Jonas In this review, we provide a brief overview over the current knowledge about the role of dopamine transmission in the prefrontal cortex during learning and memory. We discuss work in humans, monkeys, rats, and birds in order to provide a basis for comparison across species that might help identify crucial features and constraints of the dopaminergic system in executive function. Computational models of dopamine function are introduced to provide a framework for such a comparison. We also provide a brief evolutionary perspective showing that the dopaminergic system is highly preserved across mammals. Even birds, following a largely independent evolution of higher cognitive abilities, have evolved a comparable dopaminergic system. Finally, we discuss the unique advantages and challenges of using different animal models for advancing our understanding of dopamine function in the healthy and diseased brain. 2014-10-15T12:53:42Z 2014-10-15T12:53:42Z 2014-08 2014-05 Article http://purl.org/eprint/type/JournalArticle 1662-5110 http://hdl.handle.net/1721.1/90936 Puig, M. Victoria, Jonas Rose, Robert Schmidt, and Nadja Freund. “Dopamine Modulation of Learning and Memory in the Prefrontal Cortex: Insights from Studies in Primates, Rodents, and Birds.” Front. Neural Circuits. 8 (August 5, 2014). en_US http://dx.doi.org/10.3389/fncir.2014.00093 Frontiers in Neural Circuits Creative Commons Attribution http://creativecommons.org/licenses/by/4.0/ application/pdf Frontiers Research Foundation Frontiers Research Foundation |
spellingShingle | Puig, M. Victoria Rose, Jonas Schmidt, Robert Freund, Nadja Dopamine modulation of learning and memory in the prefrontal cortex: insights from studies in primates, rodents, and birds |
title | Dopamine modulation of learning and memory in the prefrontal cortex: insights from studies in primates, rodents, and birds |
title_full | Dopamine modulation of learning and memory in the prefrontal cortex: insights from studies in primates, rodents, and birds |
title_fullStr | Dopamine modulation of learning and memory in the prefrontal cortex: insights from studies in primates, rodents, and birds |
title_full_unstemmed | Dopamine modulation of learning and memory in the prefrontal cortex: insights from studies in primates, rodents, and birds |
title_short | Dopamine modulation of learning and memory in the prefrontal cortex: insights from studies in primates, rodents, and birds |
title_sort | dopamine modulation of learning and memory in the prefrontal cortex insights from studies in primates rodents and birds |
url | http://hdl.handle.net/1721.1/90936 |
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