Normalization of Plasma 25-Hydroxy Vitamin D Is Associated with Reduced Risk of Surgery in Crohn’s Disease
available in PMC 2014 August 01
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Lippincott Williams & Wilkins
2014
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| Online Access: | http://hdl.handle.net/1721.1/90945 https://orcid.org/0000-0001-8411-6403 |
| _version_ | 1826200427448762368 |
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| author | Ananthakrishnan, Ashwin N. Cagan, Andrew Gainer, Vivian Cai, Tianxi Cheng, Su-Chun Savova, Guergana Chen, Pei Szolovits, Peter Xia, Zongqi De Jager, Philip L. Shaw, Stanley Y. Churchill, Susanne Karlson, Elizabeth W. Kohane, Isaac Plenge, Robert M. Murphy, Shawn N. Liao, Katherine P. |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Ananthakrishnan, Ashwin N. Cagan, Andrew Gainer, Vivian Cai, Tianxi Cheng, Su-Chun Savova, Guergana Chen, Pei Szolovits, Peter Xia, Zongqi De Jager, Philip L. Shaw, Stanley Y. Churchill, Susanne Karlson, Elizabeth W. Kohane, Isaac Plenge, Robert M. Murphy, Shawn N. Liao, Katherine P. |
| author_sort | Ananthakrishnan, Ashwin N. |
| collection | MIT |
| description | available in PMC 2014 August 01 |
| first_indexed | 2024-09-23T11:36:18Z |
| format | Article |
| id | mit-1721.1/90945 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:36:18Z |
| publishDate | 2014 |
| publisher | Lippincott Williams & Wilkins |
| record_format | dspace |
| spelling | mit-1721.1/909452022-09-27T20:38:14Z Normalization of Plasma 25-Hydroxy Vitamin D Is Associated with Reduced Risk of Surgery in Crohn’s Disease Ananthakrishnan, Ashwin N. Cagan, Andrew Gainer, Vivian Cai, Tianxi Cheng, Su-Chun Savova, Guergana Chen, Pei Szolovits, Peter Xia, Zongqi De Jager, Philip L. Shaw, Stanley Y. Churchill, Susanne Karlson, Elizabeth W. Kohane, Isaac Plenge, Robert M. Murphy, Shawn N. Liao, Katherine P. Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Szolovits, Peter available in PMC 2014 August 01 AB Background: Vitamin D may have an immunologic role in Crohn's disease (CD) and ulcerative colitis (UC). Retrospective studies suggested a weak association between vitamin D status and disease activity but have significant limitations. Methods: Using a multi-institution inflammatory bowel disease cohort, we identified all patients with CD and UC who had at least one measured plasma 25-hydroxy vitamin D (25(OH)D). Plasma 25(OH)D was considered sufficient at levels >=30 ng/mL. Logistic regression models adjusting for potential confounders were used to identify impact of measured plasma 25(OH)D on subsequent risk of inflammatory bowel disease-related surgery or hospitalization. In a subset of patients where multiple measures of 25(OH)D were available, we examined impact of normalization of vitamin D status on study outcomes. Results: Our study included 3217 patients (55% CD; mean age, 49 yr). The median lowest plasma 25(OH)D was 26 ng/mL (interquartile range, 17-35 ng/mL). In CD, on multivariable analysis, plasma 25(OH)D <20 ng/mL was associated with an increased risk of surgery (odds ratio, 1.76; 95% confidence interval, 1.24-2.51) and inflammatory bowel disease-related hospitalization (odds ratio, 2.07; 95% confidence interval, 1.59-2.68) compared with those with 25(OH)D >=30 ng/mL. Similar estimates were also seen for UC. Furthermore, patients with CD who had initial levels <30 ng/mL but subsequently normalized their 25(OH)D had a reduced likelihood of surgery (odds ratio, 0.56; 95% confidence interval, 0.32-0.98) compared with those who remained deficient. Conclusion: Low plasma 25(OH)D is associated with increased risk of surgery and hospitalizations in both CD and UC, and normalization of 25(OH)D status is associated with a reduction in the risk of CD-related surgery. (C) Crohn's & Colitis Foundation of America, Inc. 2014-10-15T16:20:55Z 2014-10-15T16:20:55Z 2013-06 Article http://purl.org/eprint/type/JournalArticle 1078-0998 http://hdl.handle.net/1721.1/90945 Ananthakrishnan, Ashwin N., Andrew Cagan, Vivian S. Gainer, Tianxi Cai, Su-Chun Cheng, Guergana Savova, Pei Chen, et al. “Normalization of Plasma 25-Hydroxy Vitamin D Is Associated with Reduced Risk of Surgery in Crohn’s Disease.” Inflammatory Bowel Diseases (August 2013) 19(9):p.1921-1927. https://orcid.org/0000-0001-8411-6403 en_US http://dx.doi.org/10.1097/MIB.0b013e3182902ad9 Inflammatory Bowel Diseases Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Lippincott Williams & Wilkins PMC |
| spellingShingle | Ananthakrishnan, Ashwin N. Cagan, Andrew Gainer, Vivian Cai, Tianxi Cheng, Su-Chun Savova, Guergana Chen, Pei Szolovits, Peter Xia, Zongqi De Jager, Philip L. Shaw, Stanley Y. Churchill, Susanne Karlson, Elizabeth W. Kohane, Isaac Plenge, Robert M. Murphy, Shawn N. Liao, Katherine P. Normalization of Plasma 25-Hydroxy Vitamin D Is Associated with Reduced Risk of Surgery in Crohn’s Disease |
| title | Normalization of Plasma 25-Hydroxy Vitamin D Is Associated with Reduced Risk of Surgery in Crohn’s Disease |
| title_full | Normalization of Plasma 25-Hydroxy Vitamin D Is Associated with Reduced Risk of Surgery in Crohn’s Disease |
| title_fullStr | Normalization of Plasma 25-Hydroxy Vitamin D Is Associated with Reduced Risk of Surgery in Crohn’s Disease |
| title_full_unstemmed | Normalization of Plasma 25-Hydroxy Vitamin D Is Associated with Reduced Risk of Surgery in Crohn’s Disease |
| title_short | Normalization of Plasma 25-Hydroxy Vitamin D Is Associated with Reduced Risk of Surgery in Crohn’s Disease |
| title_sort | normalization of plasma 25 hydroxy vitamin d is associated with reduced risk of surgery in crohn s disease |
| url | http://hdl.handle.net/1721.1/90945 https://orcid.org/0000-0001-8411-6403 |
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