Prioritisation and Network Analysis of Crohn's Disease Susceptibility Genes
Recent Genome-Wide Association Studies (GWAS) have revealed numerous Crohn's disease susceptibility genes and a key challenge now is in understanding how risk polymorphisms in associated genes might contribute to development of this disease. For a gene to contribute to disease phenotype, its ri...
| Main Authors: | , , |
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| Format: | Article |
| Language: | en_US |
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Public Library of Science
2014
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| Online Access: | http://hdl.handle.net/1721.1/90995 |
| _version_ | 1811075552868564992 |
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| author | Muraro, Daniele Lauffenburger, Douglas A. Simmons, Alison |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Muraro, Daniele Lauffenburger, Douglas A. Simmons, Alison |
| author_sort | Muraro, Daniele |
| collection | MIT |
| description | Recent Genome-Wide Association Studies (GWAS) have revealed numerous Crohn's disease susceptibility genes and a key challenge now is in understanding how risk polymorphisms in associated genes might contribute to development of this disease. For a gene to contribute to disease phenotype, its risk variant will likely adversely communicate with a variety of other gene products to result in dysregulation of common signaling pathways. A vital challenge is to elucidate pathways of potentially greatest influence on pathological behaviour, in a manner recognizing how multiple relevant genes may yield integrative effect. In this work we apply mathematical analysis of networks involving the list of recently described Crohn's susceptibility genes, to prioritise pathways in relation to their potential development of this disease. Prioritisation was performed by applying a text mining and a diffusion based method (GRAIL, GPEC). Prospective biological significance of the resulting prioritised list of proteins is highlighted by changes in their gene expression levels in Crohn's patients intestinal tissue in comparison with healthy donors. |
| first_indexed | 2024-09-23T10:08:05Z |
| format | Article |
| id | mit-1721.1/90995 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:08:05Z |
| publishDate | 2014 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | mit-1721.1/909952022-09-30T19:06:18Z Prioritisation and Network Analysis of Crohn's Disease Susceptibility Genes Muraro, Daniele Lauffenburger, Douglas A. Simmons, Alison Massachusetts Institute of Technology. Department of Biological Engineering Lauffenburger, Douglas A. Recent Genome-Wide Association Studies (GWAS) have revealed numerous Crohn's disease susceptibility genes and a key challenge now is in understanding how risk polymorphisms in associated genes might contribute to development of this disease. For a gene to contribute to disease phenotype, its risk variant will likely adversely communicate with a variety of other gene products to result in dysregulation of common signaling pathways. A vital challenge is to elucidate pathways of potentially greatest influence on pathological behaviour, in a manner recognizing how multiple relevant genes may yield integrative effect. In this work we apply mathematical analysis of networks involving the list of recently described Crohn's susceptibility genes, to prioritise pathways in relation to their potential development of this disease. Prioritisation was performed by applying a text mining and a diffusion based method (GRAIL, GPEC). Prospective biological significance of the resulting prioritised list of proteins is highlighted by changes in their gene expression levels in Crohn's patients intestinal tissue in comparison with healthy donors. United States. Army Research Office (Institute for Collaborative Biotechnologies Contract W911NF-09-D-0001) 2014-10-20T17:32:41Z 2014-10-20T17:32:41Z 2014-09 2014-07 Article http://purl.org/eprint/type/JournalArticle 1932-6203 http://hdl.handle.net/1721.1/90995 Muraro, Daniele, Douglas A. Lauffenburger, and Alison Simmons. “Prioritisation and Network Analysis of Crohn’s Disease Susceptibility Genes.” Edited by David L. Boone. PLoS ONE 9, no. 9 (September 30, 2014): e108624. en_US http://dx.doi.org/10.1371/journal.pone.0108624 PLoS ONE Creative Commons Attribution http://creativecommons.org/licenses/by/4.0/ application/pdf Public Library of Science Public Library of Science |
| spellingShingle | Muraro, Daniele Lauffenburger, Douglas A. Simmons, Alison Prioritisation and Network Analysis of Crohn's Disease Susceptibility Genes |
| title | Prioritisation and Network Analysis of Crohn's Disease Susceptibility Genes |
| title_full | Prioritisation and Network Analysis of Crohn's Disease Susceptibility Genes |
| title_fullStr | Prioritisation and Network Analysis of Crohn's Disease Susceptibility Genes |
| title_full_unstemmed | Prioritisation and Network Analysis of Crohn's Disease Susceptibility Genes |
| title_short | Prioritisation and Network Analysis of Crohn's Disease Susceptibility Genes |
| title_sort | prioritisation and network analysis of crohn s disease susceptibility genes |
| url | http://hdl.handle.net/1721.1/90995 |
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