Dual-Phase Cardiac Diffusion Tensor Imaging with Strain Correction
Purpose: In this work we present a dual-phase diffusion tensor imaging (DTI) technique that incorporates a correction scheme for the cardiac material strain, based on 3D myocardial tagging. Methods: In vivo dual-phase cardiac DTI with a stimulated echo approach and 3D tagging was performed in 10...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Public Library of Science
2014
|
| Online Access: | http://hdl.handle.net/1721.1/91002 |
| _version_ | 1811094052061315072 |
|---|---|
| author | Stoeck, Christian T. Kalinowska, Aleksandra von Deuster, Constantin Harmer, Jack Chan, Rachel W. Niemann, Markus Manka, Robert Atkinson, David Sosnovik, David E. Mekkaoui, Choukri Kozerke, Sebastian |
| author2 | Massachusetts Institute of Technology. Center for Biomedical Engineering |
| author_facet | Massachusetts Institute of Technology. Center for Biomedical Engineering Stoeck, Christian T. Kalinowska, Aleksandra von Deuster, Constantin Harmer, Jack Chan, Rachel W. Niemann, Markus Manka, Robert Atkinson, David Sosnovik, David E. Mekkaoui, Choukri Kozerke, Sebastian |
| author_sort | Stoeck, Christian T. |
| collection | MIT |
| description | Purpose:
In this work we present a dual-phase diffusion tensor imaging (DTI) technique that incorporates a correction scheme for the cardiac material strain, based on 3D myocardial tagging.
Methods:
In vivo dual-phase cardiac DTI with a stimulated echo approach and 3D tagging was performed in 10 healthy volunteers. The time course of material strain was estimated from the tagging data and used to correct for strain effects in the diffusion weighted acquisition. Mean diffusivity, fractional anisotropy, helix, transverse and sheet angles were calculated and compared between systole and diastole, with and without strain correction. Data acquired at the systolic sweet spot, where the effects of strain are eliminated, served as a reference.
Results:
The impact of strain correction on helix angle was small. However, large differences were observed in the transverse and sheet angle values, with and without strain correction. The standard deviation of systolic transverse angles was significantly reduced from 35.9±3.9° to 27.8°±3.5° (p<0.001) upon strain-correction indicating more coherent fiber tracks after correction. Myocyte aggregate structure was aligned more longitudinally in systole compared to diastole as reflected by an increased transmural range of helix angles (71.8°±3.9° systole vs. 55.6°±5.6°, p<0.001 diastole). While diastolic sheet angle histograms had dominant counts at high sheet angle values, systolic histograms showed lower sheet angle values indicating a reorientation of myocyte sheets during contraction.
Conclusion:
An approach for dual-phase cardiac DTI with correction for material strain has been successfully implemented. This technique allows assessing dynamic changes in myofiber architecture between systole and diastole, and emphasizes the need for strain correction when sheet architecture in the heart is imaged with a stimulated echo approach. |
| first_indexed | 2024-09-23T15:54:41Z |
| format | Article |
| id | mit-1721.1/91002 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:54:41Z |
| publishDate | 2014 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | mit-1721.1/910022022-09-29T16:59:12Z Dual-Phase Cardiac Diffusion Tensor Imaging with Strain Correction Stoeck, Christian T. Kalinowska, Aleksandra von Deuster, Constantin Harmer, Jack Chan, Rachel W. Niemann, Markus Manka, Robert Atkinson, David Sosnovik, David E. Mekkaoui, Choukri Kozerke, Sebastian Massachusetts Institute of Technology. Center for Biomedical Engineering Massachusetts Institute of Technology. Department of Mechanical Engineering Kalinowska, Aleksandra Purpose: In this work we present a dual-phase diffusion tensor imaging (DTI) technique that incorporates a correction scheme for the cardiac material strain, based on 3D myocardial tagging. Methods: In vivo dual-phase cardiac DTI with a stimulated echo approach and 3D tagging was performed in 10 healthy volunteers. The time course of material strain was estimated from the tagging data and used to correct for strain effects in the diffusion weighted acquisition. Mean diffusivity, fractional anisotropy, helix, transverse and sheet angles were calculated and compared between systole and diastole, with and without strain correction. Data acquired at the systolic sweet spot, where the effects of strain are eliminated, served as a reference. Results: The impact of strain correction on helix angle was small. However, large differences were observed in the transverse and sheet angle values, with and without strain correction. The standard deviation of systolic transverse angles was significantly reduced from 35.9±3.9° to 27.8°±3.5° (p<0.001) upon strain-correction indicating more coherent fiber tracks after correction. Myocyte aggregate structure was aligned more longitudinally in systole compared to diastole as reflected by an increased transmural range of helix angles (71.8°±3.9° systole vs. 55.6°±5.6°, p<0.001 diastole). While diastolic sheet angle histograms had dominant counts at high sheet angle values, systolic histograms showed lower sheet angle values indicating a reorientation of myocyte sheets during contraction. Conclusion: An approach for dual-phase cardiac DTI with correction for material strain has been successfully implemented. This technique allows assessing dynamic changes in myofiber architecture between systole and diastole, and emphasizes the need for strain correction when sheet architecture in the heart is imaged with a stimulated echo approach. National Institutes of Health (U.S.) (5R01HL112831) 2014-10-20T18:20:24Z 2014-10-20T18:20:24Z 2014-09 2014-05 Article http://purl.org/eprint/type/JournalArticle 1932-6203 http://hdl.handle.net/1721.1/91002 Stoeck, Christian T., Aleksandra Kalinowska, Constantin von Deuster, Jack Harmer, Rachel W. Chan, Markus Niemann, Robert Manka, et al. “Dual-Phase Cardiac Diffusion Tensor Imaging with Strain Correction.” Edited by Alexander Leemans. PLoS ONE 9, no. 9 (September 5, 2014): e107159. en_US http://dx.doi.org/10.1371/journal.pone.0107159 PLoS ONE Creative Commons Attribution http://creativecommons.org/licenses/by/4.0/ application/pdf Public Library of Science Public Library of Science |
| spellingShingle | Stoeck, Christian T. Kalinowska, Aleksandra von Deuster, Constantin Harmer, Jack Chan, Rachel W. Niemann, Markus Manka, Robert Atkinson, David Sosnovik, David E. Mekkaoui, Choukri Kozerke, Sebastian Dual-Phase Cardiac Diffusion Tensor Imaging with Strain Correction |
| title | Dual-Phase Cardiac Diffusion Tensor Imaging with Strain Correction |
| title_full | Dual-Phase Cardiac Diffusion Tensor Imaging with Strain Correction |
| title_fullStr | Dual-Phase Cardiac Diffusion Tensor Imaging with Strain Correction |
| title_full_unstemmed | Dual-Phase Cardiac Diffusion Tensor Imaging with Strain Correction |
| title_short | Dual-Phase Cardiac Diffusion Tensor Imaging with Strain Correction |
| title_sort | dual phase cardiac diffusion tensor imaging with strain correction |
| url | http://hdl.handle.net/1721.1/91002 |
| work_keys_str_mv | AT stoeckchristiant dualphasecardiacdiffusiontensorimagingwithstraincorrection AT kalinowskaaleksandra dualphasecardiacdiffusiontensorimagingwithstraincorrection AT vondeusterconstantin dualphasecardiacdiffusiontensorimagingwithstraincorrection AT harmerjack dualphasecardiacdiffusiontensorimagingwithstraincorrection AT chanrachelw dualphasecardiacdiffusiontensorimagingwithstraincorrection AT niemannmarkus dualphasecardiacdiffusiontensorimagingwithstraincorrection AT mankarobert dualphasecardiacdiffusiontensorimagingwithstraincorrection AT atkinsondavid dualphasecardiacdiffusiontensorimagingwithstraincorrection AT sosnovikdavide dualphasecardiacdiffusiontensorimagingwithstraincorrection AT mekkaouichoukri dualphasecardiacdiffusiontensorimagingwithstraincorrection AT kozerkesebastian dualphasecardiacdiffusiontensorimagingwithstraincorrection |