Development of siRNA-probes for studying intracellular trafficking of siRNA nanoparticles

One important barrier facing the delivery of short interfering RNAs (siRNAs) via synthetic nanoparticles is the rate of nanoparticle disassembly. However, our ability to optimize the release kinetics of siRNAs from nanoparticles for maximum efficacy is limited by the lack of methods to track their i...

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Bibliographic Details
Main Authors: Alabi, Christopher A., Sahay, Gaurav, Anderson, Daniel Griffith, Langer, Robert S
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: Royal Society of Chemistry 2014
Online Access:http://hdl.handle.net/1721.1/91143
https://orcid.org/0000-0002-2100-1171
https://orcid.org/0000-0001-5629-4798
https://orcid.org/0000-0003-4255-0492