Increased tRNA modification and gene-specific codon usage regulate cell cycle progression during the DNA damage response

Increased tRNA modification and gene-specific codon usage regulate cell cycle progression during the DNA damage response

S-phase and DNA damage promote increased ribonucleotide reductase (RNR) activity. Translation of RNR1 has been linked to the wobble uridine modifying enzyme tRNA methyltransferase 9 (Trm9). We predicted that changes in tRNA modification would translationally regulate RNR1 after DNA damage to promote...

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Bibliographic Details
Main Authors: Patil, Ashish, Dyavaiah, Madhu, Joseph, Fraulin, Rooney, John P., Chan, Tsz Yan Clement, Dedon, Peter C., Begley, Thomas J.
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences
Format: Article
Language:en_US
Published: Taylor & Francis 2014
Online Access:http://hdl.handle.net/1721.1/91232
https://orcid.org/0000-0003-0011-3067
https://orcid.org/0000-0001-7940-3459

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