Suspended nanochannel resonators at attogram precision
Nanomechanical resonators can quantify individual particles down to a single atom; however the applications are limited due to their degraded performance in solution. Suspended micro- and nanochannel resonators can achieve vacuum level performances for samples in solution since the target analyte fl...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Institute of Electrical and Electronics Engineers (IEEE)
2014
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| Online Access: | http://hdl.handle.net/1721.1/91238 https://orcid.org/0000-0001-5223-9433 https://orcid.org/0000-0002-5866-4606 https://orcid.org/0000-0001-5277-6060 |
| _version_ | 1811096404583514112 |
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| author | Cermak, Nathan Payer, Kristofor Robert Shen, Wenjiang Lee, Jungchul Olcum, Selim A. Wasserman, Steven Manalis, Scott R |
| author2 | Massachusetts Institute of Technology. Computational and Systems Biology Program |
| author_facet | Massachusetts Institute of Technology. Computational and Systems Biology Program Cermak, Nathan Payer, Kristofor Robert Shen, Wenjiang Lee, Jungchul Olcum, Selim A. Wasserman, Steven Manalis, Scott R |
| author_sort | Cermak, Nathan |
| collection | MIT |
| description | Nanomechanical resonators can quantify individual particles down to a single atom; however the applications are limited due to their degraded performance in solution. Suspended micro- and nanochannel resonators can achieve vacuum level performances for samples in solution since the target analyte flows through an integrated channel within the resonator. Here we report on a new generation suspended nanochannel resonator (SNR) that operates at approximately 2 MHz with quality factors between 10,000-20,000. The SNR is measured to have a mass sensitivity of 8.2 mHz/attogram. With an optimized oscillator system, we show that the resonator can be oscillated with a mass equivalent frequency stability of 0.85 attogram (4 parts-perbillion) at 1 kHz bandwidth, which is 1.8 times the calculated stability imposed by the thermal noise. We demonstrate the use of this mass resolution by quantifying the mass and concentration of nanoparticles down to 10 nm in solution. |
| first_indexed | 2024-09-23T16:43:13Z |
| format | Article |
| id | mit-1721.1/91238 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:43:13Z |
| publishDate | 2014 |
| publisher | Institute of Electrical and Electronics Engineers (IEEE) |
| record_format | dspace |
| spelling | mit-1721.1/912382022-10-03T07:47:20Z Suspended nanochannel resonators at attogram precision Cermak, Nathan Payer, Kristofor Robert Shen, Wenjiang Lee, Jungchul Olcum, Selim A. Wasserman, Steven Manalis, Scott R Massachusetts Institute of Technology. Computational and Systems Biology Program Massachusetts Institute of Technology. Department of Biological Engineering Koch Institute for Integrative Cancer Research at MIT Manalis, Scott R. Manalis, Scott R. Olcum, Selim Cermak, Nathan Wasserman, Steven Charles Payer, Kristofor Robert Nanomechanical resonators can quantify individual particles down to a single atom; however the applications are limited due to their degraded performance in solution. Suspended micro- and nanochannel resonators can achieve vacuum level performances for samples in solution since the target analyte flows through an integrated channel within the resonator. Here we report on a new generation suspended nanochannel resonator (SNR) that operates at approximately 2 MHz with quality factors between 10,000-20,000. The SNR is measured to have a mass sensitivity of 8.2 mHz/attogram. With an optimized oscillator system, we show that the resonator can be oscillated with a mass equivalent frequency stability of 0.85 attogram (4 parts-perbillion) at 1 kHz bandwidth, which is 1.8 times the calculated stability imposed by the thermal noise. We demonstrate the use of this mass resolution by quantifying the mass and concentration of nanoparticles down to 10 nm in solution. 2014-10-30T14:34:10Z 2014-10-30T14:34:10Z 2014-01 Article http://purl.org/eprint/type/ConferencePaper 978-1-4799-3509-3 http://hdl.handle.net/1721.1/91238 Olcum, Selim, Nathan Cermak, Steven C. Wasserman, Kris Payer, Wenjiang Shen, Jungchul Lee, and Scott R. Manalis. “Suspended Nanochannel Resonators at Attogram Precision.” 2014 IEEE 27th International Conference on Micro Electro Mechanical Systems (MEMS) (January 2014). https://orcid.org/0000-0001-5223-9433 https://orcid.org/0000-0002-5866-4606 https://orcid.org/0000-0001-5277-6060 en_US http://dx.doi.org/10.1109/MEMSYS.2014.6765587 2014 IEEE 27th International Conference on Micro Electro Mechanical Systems (MEMS) Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Institute of Electrical and Electronics Engineers (IEEE) Prof. Manalis via Howard Silver |
| spellingShingle | Cermak, Nathan Payer, Kristofor Robert Shen, Wenjiang Lee, Jungchul Olcum, Selim A. Wasserman, Steven Manalis, Scott R Suspended nanochannel resonators at attogram precision |
| title | Suspended nanochannel resonators at attogram precision |
| title_full | Suspended nanochannel resonators at attogram precision |
| title_fullStr | Suspended nanochannel resonators at attogram precision |
| title_full_unstemmed | Suspended nanochannel resonators at attogram precision |
| title_short | Suspended nanochannel resonators at attogram precision |
| title_sort | suspended nanochannel resonators at attogram precision |
| url | http://hdl.handle.net/1721.1/91238 https://orcid.org/0000-0001-5223-9433 https://orcid.org/0000-0002-5866-4606 https://orcid.org/0000-0001-5277-6060 |
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