Npas4 Regulates a Transcriptional Program in CA3 Required for Contextual Memory Formation
available in PMC 2014 May 29
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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American Association for the Advancement of Science (AAAS)
2014
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| Online Access: | http://hdl.handle.net/1721.1/91240 https://orcid.org/0000-0002-7002-1275 https://orcid.org/0000-0002-3854-5968 |
| _version_ | 1826200785420025856 |
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| author | Ramamoorthi, Kartik Fropf, Robin Belfort, Gabriel M. Fitzmaurice, Helen L. McKinney, Ross M. Neve, Rachael L. Otto, Tim Lin, Yingxi |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Ramamoorthi, Kartik Fropf, Robin Belfort, Gabriel M. Fitzmaurice, Helen L. McKinney, Ross M. Neve, Rachael L. Otto, Tim Lin, Yingxi |
| author_sort | Ramamoorthi, Kartik |
| collection | MIT |
| description | available in PMC 2014 May 29 |
| first_indexed | 2024-09-23T11:41:43Z |
| format | Article |
| id | mit-1721.1/91240 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:41:43Z |
| publishDate | 2014 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | dspace |
| spelling | mit-1721.1/912402022-10-01T05:18:36Z Npas4 Regulates a Transcriptional Program in CA3 Required for Contextual Memory Formation Ramamoorthi, Kartik Fropf, Robin Belfort, Gabriel M. Fitzmaurice, Helen L. McKinney, Ross M. Neve, Rachael L. Otto, Tim Lin, Yingxi Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences McGovern Institute for Brain Research at MIT Ramamoorthi, Kartik Fropf, Robin Belfort, Gabriel M. Fitzmaurice, Helen L. McKinney, Ross M. Neve, Rachael L. Lin, Yingxi available in PMC 2014 May 29 The rapid encoding of contextual memory requires the CA3 region of the hippocampus, but the necessary genetic pathways remain unclear. We found that the activity-dependent transcription factor Npas4 regulates a transcriptional program in CA3 that is required for contextual memory formation. Npas4 was specifically expressed in CA3 after contextual learning. Global knockout or selective deletion of Npas4 in CA3 both resulted in impaired contextual memory, and restoration of Npas4 in CA3 was sufficient to reverse the deficit in global knockout mice. By recruiting RNA polymerase II to promoters and enhancers of target genes, Npas4 regulates a learning-specific transcriptional program in CA3 that includes many well-known activity-regulated genes, which suggests that Npas4 is a master regulator of activity-regulated gene programs and is central to memory formation. McGovern Institute for Brain Research at MIT Massachusetts Institute of Technology (MIT Presidential Marcus Fellowship to Honor Norman B. Leventhal) Massachusetts Institute of Technology. Simons Center for the Social Brain National Science Foundation (U.S.) (NSF grant IOS 0919159) Whitehall Foundation (research grant) Anonymous Foundation John Merck Fund (John Merck Scholars Program) National Institutes of Health (U.S.) (NIH grant MH091220-01) 2014-10-30T15:39:55Z 2014-10-30T15:39:55Z 2011-12 2011-05 Article http://purl.org/eprint/type/JournalArticle 0036-8075 1095-9203 http://hdl.handle.net/1721.1/91240 Ramamoorthi, K., R. Fropf, G. M. Belfort, H. L. Fitzmaurice, R. M. McKinney, R. L. Neve, T. Otto, and Y. Lin. “Npas4 Regulates a Transcriptional Program in CA3 Required for Contextual Memory Formation.” Science 334, no. 6063 (December 22, 2011): 1669–1675. https://orcid.org/0000-0002-7002-1275 https://orcid.org/0000-0002-3854-5968 en_US http://dx.doi.org/10.1126/science.1208049 Science Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Association for the Advancement of Science (AAAS) PMC |
| spellingShingle | Ramamoorthi, Kartik Fropf, Robin Belfort, Gabriel M. Fitzmaurice, Helen L. McKinney, Ross M. Neve, Rachael L. Otto, Tim Lin, Yingxi Npas4 Regulates a Transcriptional Program in CA3 Required for Contextual Memory Formation |
| title | Npas4 Regulates a Transcriptional Program in CA3 Required for Contextual Memory Formation |
| title_full | Npas4 Regulates a Transcriptional Program in CA3 Required for Contextual Memory Formation |
| title_fullStr | Npas4 Regulates a Transcriptional Program in CA3 Required for Contextual Memory Formation |
| title_full_unstemmed | Npas4 Regulates a Transcriptional Program in CA3 Required for Contextual Memory Formation |
| title_short | Npas4 Regulates a Transcriptional Program in CA3 Required for Contextual Memory Formation |
| title_sort | npas4 regulates a transcriptional program in ca3 required for contextual memory formation |
| url | http://hdl.handle.net/1721.1/91240 https://orcid.org/0000-0002-7002-1275 https://orcid.org/0000-0002-3854-5968 |
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