Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability
Degradable, cationic poly(β-amino ester)s (PBAEs) with alkyl side chains are developed for non-viral gene delivery. Nanoparticles formed from these PBAE terpolymers exhibit significantly enhanced DNA transfection potency and resistance to aggregation. These hydrophobic PBAE terpolymers, but not PBAE...
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| Format: | Article |
| Language: | en_US |
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Wiley-VCH Verlag GmbH & Co.
2014
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| Online Access: | http://hdl.handle.net/1721.1/91242 https://orcid.org/0000-0001-5629-4798 https://orcid.org/0000-0003-4255-0492 |
| _version_ | 1826192427683151872 |
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| author | Eltoukhy, Ahmed A. Chen, Delai Alabi, Christopher A. Anderson, Daniel Griffith Langer, Robert S |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Eltoukhy, Ahmed A. Chen, Delai Alabi, Christopher A. Anderson, Daniel Griffith Langer, Robert S |
| author_sort | Eltoukhy, Ahmed A. |
| collection | MIT |
| description | Degradable, cationic poly(β-amino ester)s (PBAEs) with alkyl side chains are developed for non-viral gene delivery. Nanoparticles formed from these PBAE terpolymers exhibit significantly enhanced DNA transfection potency and resistance to aggregation. These hydrophobic PBAE terpolymers, but not PBAEs lacking alkyl side chains, support interaction with PEG-lipid conjugates, facilitating their functionalization with shielding and targeting moieties and accelerating the in vivo translation of these materials. |
| first_indexed | 2024-09-23T09:12:29Z |
| format | Article |
| id | mit-1721.1/91242 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:12:29Z |
| publishDate | 2014 |
| publisher | Wiley-VCH Verlag GmbH & Co. |
| record_format | dspace |
| spelling | mit-1721.1/912422022-09-26T11:03:01Z Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability Eltoukhy, Ahmed A. Chen, Delai Alabi, Christopher A. Anderson, Daniel Griffith Langer, Robert S Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Chemical Engineering Koch Institute for Integrative Cancer Research at MIT Eltoukhy, Ahmed A. Chen, Delai Langer, Robert Anderson, Daniel Griffith Degradable, cationic poly(β-amino ester)s (PBAEs) with alkyl side chains are developed for non-viral gene delivery. Nanoparticles formed from these PBAE terpolymers exhibit significantly enhanced DNA transfection potency and resistance to aggregation. These hydrophobic PBAE terpolymers, but not PBAEs lacking alkyl side chains, support interaction with PEG-lipid conjugates, facilitating their functionalization with shielding and targeting moieties and accelerating the in vivo translation of these materials. National Heart, Lung, and Blood Institute National Institutes of Health (U.S.) (Program of Excellence in Nanotechnology (PEN) Award, Contract #HHSN268201000045C) National Institutes of Health (U.S.) (NIH Grant R01-EB000244-27) National Institutes of Health (U.S.) (NIH Grant 5-R01-CA132091-04) National Institutes of Health (U.S.) (NIH Grant R01-DE016516-03) National Science Foundation (U.S.) (Graduate Research Fellowship) Juvenile Diabetes Research Foundation International (Grant 17–2007-1063) 2014-10-30T19:05:13Z 2014-10-30T19:05:13Z 2013-03 2012-11 Article http://purl.org/eprint/type/JournalArticle 09359648 http://hdl.handle.net/1721.1/91242 Eltoukhy, Ahmed A., Delai Chen, Christopher A. Alabi, Robert Langer, and Daniel G. Anderson. “Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability.” Advanced Materials 25, no. 10 (January 4, 2013): 1487–1493. https://orcid.org/0000-0001-5629-4798 https://orcid.org/0000-0003-4255-0492 en_US http://dx.doi.org/10.1002/adma.201204346 Advanced Materials Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wiley-VCH Verlag GmbH & Co. PMC |
| spellingShingle | Eltoukhy, Ahmed A. Chen, Delai Alabi, Christopher A. Anderson, Daniel Griffith Langer, Robert S Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability |
| title | Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability |
| title_full | Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability |
| title_fullStr | Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability |
| title_full_unstemmed | Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability |
| title_short | Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability |
| title_sort | degradable terpolymers with alkyl side chains demonstrate enhanced gene delivery potency and nanoparticle stability |
| url | http://hdl.handle.net/1721.1/91242 https://orcid.org/0000-0001-5629-4798 https://orcid.org/0000-0003-4255-0492 |
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