Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability

Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability

Degradable, cationic poly(β-amino ester)s (PBAEs) with alkyl side chains are developed for non-viral gene delivery. Nanoparticles formed from these PBAE terpolymers exhibit significantly enhanced DNA transfection potency and resistance to aggregation. These hydrophobic PBAE terpolymers, but not PBAE...

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Bibliographic Details
Main Authors: Eltoukhy, Ahmed A., Chen, Delai, Alabi, Christopher A., Anderson, Daniel Griffith, Langer, Robert S
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: Wiley-VCH Verlag GmbH & Co. 2014
Online Access:http://hdl.handle.net/1721.1/91242
https://orcid.org/0000-0001-5629-4798
https://orcid.org/0000-0003-4255-0492

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