Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

Despite efforts to understand the interactions between nanoparticles and cells, the cellular processes that determine the efficiency of intracellular drug delivery remain unclear. Here we examine cellular uptake of short interfering RNA (siRNA) delivered in lipid nanoparticles (LNPs) using cellular...

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Detaylı Bibliyografya
Asıl Yazarlar: Sahay, Gaurav, Querbes, William, Alabi, Christopher A., Eltoukhy, Ahmed A., Sarkar, Sovan, Zurenko, Christopher, Karagiannis, Emmanouil, Love, Kevin T., Chen, Delai, Zoncu, Roberto, Buganim, Yosef, Schroeder, Avi, Langer, Robert, Anderson, Daniel Griffith
Diğer Yazarlar: Massachusetts Institute of Technology. Department of Chemical Engineering
Materyal Türü: Makale
Dil:en_US
Baskı/Yayın Bilgisi: 2014
Online Erişim:http://hdl.handle.net/1721.1/91243
https://orcid.org/0000-0002-2100-1171
https://orcid.org/0000-0003-0131-6552
https://orcid.org/0000-0001-5629-4798
https://orcid.org/0000-0003-4255-0492