Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

Despite efforts to understand the interactions between nanoparticles and cells, the cellular processes that determine the efficiency of intracellular drug delivery remain unclear. Here we examine cellular uptake of short interfering RNA (siRNA) delivered in lipid nanoparticles (LNPs) using cellular...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Sahay, Gaurav, Querbes, William, Alabi, Christopher A., Eltoukhy, Ahmed A., Sarkar, Sovan, Zurenko, Christopher, Karagiannis, Emmanouil, Love, Kevin T., Chen, Delai, Zoncu, Roberto, Buganim, Yosef, Schroeder, Avi, Langer, Robert, Anderson, Daniel Griffith
Weitere Verfasser: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Artikel
Sprache:en_US
Veröffentlicht: 2014
Online Zugang:http://hdl.handle.net/1721.1/91243
https://orcid.org/0000-0002-2100-1171
https://orcid.org/0000-0003-0131-6552
https://orcid.org/0000-0001-5629-4798
https://orcid.org/0000-0003-4255-0492

Online

http://hdl.handle.net/1721.1/91243
https://orcid.org/0000-0002-2100-1171
https://orcid.org/0000-0003-0131-6552
https://orcid.org/0000-0001-5629-4798
https://orcid.org/0000-0003-4255-0492

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