Lipid-Modified Aminoglycoside Derivatives for In Vivo siRNA Delivery

Lipid-Modified Aminoglycoside Derivatives for In Vivo siRNA Delivery

Rationally designed siRNA delivery materials that are enabled by lipid-modified aminoglycosides are demonstrated. Leading materials identified are able to self-assemble with siRNA into well-defined nanoparticles and induce efficient gene knockdown both in vitro and in vivo. Histology studies and liv...

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Bibliographic Details
Main Authors: Zhang, Yunlong, Heller, Daniel A., Dong, Yizhou, Chen, Delai, Gu, Zhen, Joseph, Brian J., Wallas, Jasmine, Anderson, Daniel Griffith, Pelet, Jeisa
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:en_US
Published: Wiley-VCH Verlag GmbH & Co. 2014
Online Access:http://hdl.handle.net/1721.1/91256
https://orcid.org/0000-0001-5629-4798

Internet

http://hdl.handle.net/1721.1/91256
https://orcid.org/0000-0001-5629-4798

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