A nanofluidic device for single molecule studies with in situ control of environmental solution conditions

We report an approach to study the in situ conformational response of single biomolecules such as DNA to a change in environmental solution conditions. These conditions are, for example, the composition of the buffer or the presence of protein. For this purpose, we designed and fabricated a nanoflui...

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Bibliographic Details
Main Authors: Zhang, Ce, Jiang, Kai, Liu, Fan, Doyle, Patrick S., van Kan, Jeroen A., van der Maarel, Johan R. C.
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:en_US
Published: Royal Society of Chemistry, The 2014
Online Access:http://hdl.handle.net/1721.1/91270