Modular ‘Click-in-Emulsion’ Bone-Targeted Nanogels

Modular ‘Click-in-Emulsion’ Bone-Targeted Nanogels

A new class of nanogel demonstrates modular biodistribution and affinity for bone. Nanogels, ~70 nm in diameter and synthesized via an astoichiometric click-chemistry in-emulsion method, controllably display residual, free clickable functional groups. Functionalization with a bisphosphonate ligand r...

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Bibliographic Details
Main Authors: Heller, Daniel A., Levi, Yair, Wallas, Jasmine, Pratt, George W., Jiang, Shan, Sahay, Gaurav, Schroeder, Josh E., Chyan, Yieu, Zurenko, Christopher, Querbes, William, Manzano, Miguel, Kohane, Daniel S., Anderson, Daniel Griffith, Pelet, Jeisa, Doloff, Joshua C, Schroeder, Avraham Dror, Langer, Robert S
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: Wiley Blackwell 2014
Online Access:http://hdl.handle.net/1721.1/91484
https://orcid.org/0000-0002-2100-1171
https://orcid.org/0000-0001-5629-4798
https://orcid.org/0000-0002-4323-3264
https://orcid.org/0000-0003-4255-0492
Description
Summary:A new class of nanogel demonstrates modular biodistribution and affinity for bone. Nanogels, ~70 nm in diameter and synthesized via an astoichiometric click-chemistry in-emulsion method, controllably display residual, free clickable functional groups. Functionalization with a bisphosphonate ligand results in significant binding to bone on the inner walls of marrow cavities, liver avoidance, and anti-osteoporotic effects.

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