Modular ‘Click-in-Emulsion’ Bone-Targeted Nanogels
A new class of nanogel demonstrates modular biodistribution and affinity for bone. Nanogels, ~70 nm in diameter and synthesized via an astoichiometric click-chemistry in-emulsion method, controllably display residual, free clickable functional groups. Functionalization with a bisphosphonate ligand r...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Wiley Blackwell
2014
|
| Online Access: | http://hdl.handle.net/1721.1/91484 https://orcid.org/0000-0002-2100-1171 https://orcid.org/0000-0001-5629-4798 https://orcid.org/0000-0002-4323-3264 https://orcid.org/0000-0003-4255-0492 |
| _version_ | 1826212060036333568 |
|---|---|
| author | Heller, Daniel A. Levi, Yair Wallas, Jasmine Pratt, George W. Jiang, Shan Sahay, Gaurav Schroeder, Josh E. Chyan, Yieu Zurenko, Christopher Querbes, William Manzano, Miguel Kohane, Daniel S. Anderson, Daniel Griffith Pelet, Jeisa Doloff, Joshua C Schroeder, Avraham Dror Langer, Robert S |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Heller, Daniel A. Levi, Yair Wallas, Jasmine Pratt, George W. Jiang, Shan Sahay, Gaurav Schroeder, Josh E. Chyan, Yieu Zurenko, Christopher Querbes, William Manzano, Miguel Kohane, Daniel S. Anderson, Daniel Griffith Pelet, Jeisa Doloff, Joshua C Schroeder, Avraham Dror Langer, Robert S |
| author_sort | Heller, Daniel A. |
| collection | MIT |
| description | A new class of nanogel demonstrates modular biodistribution and affinity for bone. Nanogels, ~70 nm in diameter and synthesized via an astoichiometric click-chemistry in-emulsion method, controllably display residual, free clickable functional groups. Functionalization with a bisphosphonate ligand results in significant binding to bone on the inner walls of marrow cavities, liver avoidance, and anti-osteoporotic effects. |
| first_indexed | 2024-09-23T15:15:30Z |
| format | Article |
| id | mit-1721.1/91484 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:15:30Z |
| publishDate | 2014 |
| publisher | Wiley Blackwell |
| record_format | dspace |
| spelling | mit-1721.1/914842022-09-29T13:42:47Z Modular ‘Click-in-Emulsion’ Bone-Targeted Nanogels Heller, Daniel A. Levi, Yair Wallas, Jasmine Pratt, George W. Jiang, Shan Sahay, Gaurav Schroeder, Josh E. Chyan, Yieu Zurenko, Christopher Querbes, William Manzano, Miguel Kohane, Daniel S. Anderson, Daniel Griffith Pelet, Jeisa Doloff, Joshua C Schroeder, Avraham Dror Langer, Robert S Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Chemical Engineering Koch Institute for Integrative Cancer Research at MIT Heller, Daniel A. Levi, Yair Pelet, Jeisa M. Doloff, Joshua C. Wallas, Jasmine Pratt, George W. Jiang, Shan Sahay, Gaurav Schroeder, Avi Chyan, Yieu Manzano, Miguel Langer, Robert Anderson, Daniel Griffith A new class of nanogel demonstrates modular biodistribution and affinity for bone. Nanogels, ~70 nm in diameter and synthesized via an astoichiometric click-chemistry in-emulsion method, controllably display residual, free clickable functional groups. Functionalization with a bisphosphonate ligand results in significant binding to bone on the inner walls of marrow cavities, liver avoidance, and anti-osteoporotic effects. National Institutes of Health (U.S.) (RO1 DE016516) National Institutes of Health (U.S.) (R01 EB000244) Damon Runyon Cancer Research Foundation (DFS-#2050-10) 2014-11-07T13:31:27Z 2014-11-07T13:31:27Z 2012-12 2012-10 Article http://purl.org/eprint/type/JournalArticle 09359648 1521-4095 http://hdl.handle.net/1721.1/91484 Heller, Daniel A., Yair Levi, Jeisa M. Pelet, Joshua C. Doloff, Jasmine Wallas, George W. Pratt, Shan Jiang, et al. “Modular ‘Click-in-Emulsion’ Bone-Targeted Nanogels.” Advanced Materials 25, no. 10 (December 27, 2012): 1449–1454. https://orcid.org/0000-0002-2100-1171 https://orcid.org/0000-0001-5629-4798 https://orcid.org/0000-0002-4323-3264 https://orcid.org/0000-0003-4255-0492 en_US http://dx.doi.org/10.1002/adma.201202881 Advanced Materials Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wiley Blackwell PMC |
| spellingShingle | Heller, Daniel A. Levi, Yair Wallas, Jasmine Pratt, George W. Jiang, Shan Sahay, Gaurav Schroeder, Josh E. Chyan, Yieu Zurenko, Christopher Querbes, William Manzano, Miguel Kohane, Daniel S. Anderson, Daniel Griffith Pelet, Jeisa Doloff, Joshua C Schroeder, Avraham Dror Langer, Robert S Modular ‘Click-in-Emulsion’ Bone-Targeted Nanogels |
| title | Modular ‘Click-in-Emulsion’ Bone-Targeted Nanogels |
| title_full | Modular ‘Click-in-Emulsion’ Bone-Targeted Nanogels |
| title_fullStr | Modular ‘Click-in-Emulsion’ Bone-Targeted Nanogels |
| title_full_unstemmed | Modular ‘Click-in-Emulsion’ Bone-Targeted Nanogels |
| title_short | Modular ‘Click-in-Emulsion’ Bone-Targeted Nanogels |
| title_sort | modular click in emulsion bone targeted nanogels |
| url | http://hdl.handle.net/1721.1/91484 https://orcid.org/0000-0002-2100-1171 https://orcid.org/0000-0001-5629-4798 https://orcid.org/0000-0002-4323-3264 https://orcid.org/0000-0003-4255-0492 |
| work_keys_str_mv | AT hellerdaniela modularclickinemulsionbonetargetednanogels AT leviyair modularclickinemulsionbonetargetednanogels AT wallasjasmine modularclickinemulsionbonetargetednanogels AT prattgeorgew modularclickinemulsionbonetargetednanogels AT jiangshan modularclickinemulsionbonetargetednanogels AT sahaygaurav modularclickinemulsionbonetargetednanogels AT schroederjoshe modularclickinemulsionbonetargetednanogels AT chyanyieu modularclickinemulsionbonetargetednanogels AT zurenkochristopher modularclickinemulsionbonetargetednanogels AT querbeswilliam modularclickinemulsionbonetargetednanogels AT manzanomiguel modularclickinemulsionbonetargetednanogels AT kohanedaniels modularclickinemulsionbonetargetednanogels AT andersondanielgriffith modularclickinemulsionbonetargetednanogels AT peletjeisa modularclickinemulsionbonetargetednanogels AT doloffjoshuac modularclickinemulsionbonetargetednanogels AT schroederavrahamdror modularclickinemulsionbonetargetednanogels AT langerroberts modularclickinemulsionbonetargetednanogels |