Modular ‘Click-in-Emulsion’ Bone-Targeted Nanogels
A new class of nanogel demonstrates modular biodistribution and affinity for bone. Nanogels, ~70 nm in diameter and synthesized via an astoichiometric click-chemistry in-emulsion method, controllably display residual, free clickable functional groups. Functionalization with a bisphosphonate ligand r...
Main Authors: | Heller, Daniel A., Levi, Yair, Wallas, Jasmine, Pratt, George W., Jiang, Shan, Sahay, Gaurav, Schroeder, Josh E., Chyan, Yieu, Zurenko, Christopher, Querbes, William, Manzano, Miguel, Kohane, Daniel S., Anderson, Daniel Griffith, Pelet, Jeisa, Doloff, Joshua C, Schroeder, Avraham Dror, Langer, Robert S |
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Other Authors: | Harvard University--MIT Division of Health Sciences and Technology |
Format: | Article |
Language: | en_US |
Published: |
Wiley Blackwell
2014
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Online Access: | http://hdl.handle.net/1721.1/91484 https://orcid.org/0000-0002-2100-1171 https://orcid.org/0000-0001-5629-4798 https://orcid.org/0000-0002-4323-3264 https://orcid.org/0000-0003-4255-0492 |
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