Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform
We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and the targeting ligands become available for binding. The concept was evaluated...
| Main Authors: | , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Royal Society of Chemistry
2014
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| Online Access: | http://hdl.handle.net/1721.1/91497 https://orcid.org/0000-0003-4255-0492 |
| _version_ | 1811084029584211968 |
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| author | Gianella, Anita Mieszawska, Aneta J. Hoeben, Freek J. M. Janssen, Henk M. Jarzyna, Peter A. Cormode, David P. Costa, Kevin D. Rao, Satish Farokhzad, Omid C. Langer, Robert Fayad, Zahi A. Mulder, Willem J. M. |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Gianella, Anita Mieszawska, Aneta J. Hoeben, Freek J. M. Janssen, Henk M. Jarzyna, Peter A. Cormode, David P. Costa, Kevin D. Rao, Satish Farokhzad, Omid C. Langer, Robert Fayad, Zahi A. Mulder, Willem J. M. |
| author_sort | Gianella, Anita |
| collection | MIT |
| description | We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and the targeting ligands become available for binding. The concept was evaluated in vitro using biotin and αvβ3-integrin-specific RGD-peptide functionalized nanoparticles. |
| first_indexed | 2024-09-23T12:43:28Z |
| format | Article |
| id | mit-1721.1/91497 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T12:43:28Z |
| publishDate | 2014 |
| publisher | Royal Society of Chemistry |
| record_format | dspace |
| spelling | mit-1721.1/914972022-10-01T10:44:34Z Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform Gianella, Anita Mieszawska, Aneta J. Hoeben, Freek J. M. Janssen, Henk M. Jarzyna, Peter A. Cormode, David P. Costa, Kevin D. Rao, Satish Farokhzad, Omid C. Langer, Robert Fayad, Zahi A. Mulder, Willem J. M. Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Chemical Engineering Langer, Robert We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and the targeting ligands become available for binding. The concept was evaluated in vitro using biotin and αvβ3-integrin-specific RGD-peptide functionalized nanoparticles. National Heart, Lung, and Blood Institute National Institutes of Health (U.S.) (Program of Excellence in Nanotechnology (PEN) Award Contract HHSN268201000045C) 2014-11-07T16:12:07Z 2014-11-07T16:12:07Z 2013-07 2013-05 Article http://purl.org/eprint/type/JournalArticle 1359-7345 1364-548X http://hdl.handle.net/1721.1/91497 Gianella, Anita, Aneta J. Mieszawska, Freek J. M. Hoeben, Henk M. Janssen, Peter A. Jarzyna, David P. Cormode, Kevin D. Costa, et al. “Synthesis and in Vitro Evaluation of a Multifunctional and Surface-Switchable Nanoemulsion Platform.” Chemical Communications 49, no. 82 (2013): 9392. https://orcid.org/0000-0003-4255-0492 en_US http://dx.doi.org/10.1039/c3cc43618g Chemical Communications Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Royal Society of Chemistry PMC |
| spellingShingle | Gianella, Anita Mieszawska, Aneta J. Hoeben, Freek J. M. Janssen, Henk M. Jarzyna, Peter A. Cormode, David P. Costa, Kevin D. Rao, Satish Farokhzad, Omid C. Langer, Robert Fayad, Zahi A. Mulder, Willem J. M. Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform |
| title | Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform |
| title_full | Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform |
| title_fullStr | Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform |
| title_full_unstemmed | Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform |
| title_short | Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform |
| title_sort | synthesis and in vitro evaluation of a multifunctional and surface switchable nanoemulsion platform |
| url | http://hdl.handle.net/1721.1/91497 https://orcid.org/0000-0003-4255-0492 |
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