Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform
We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and the targeting ligands become available for binding. The concept was evaluated...
Main Authors: | Gianella, Anita, Mieszawska, Aneta J., Hoeben, Freek J. M., Janssen, Henk M., Jarzyna, Peter A., Cormode, David P., Costa, Kevin D., Rao, Satish, Farokhzad, Omid C., Langer, Robert, Fayad, Zahi A., Mulder, Willem J. M. |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Biological Engineering |
Format: | Article |
Language: | en_US |
Published: |
Royal Society of Chemistry
2014
|
Online Access: | http://hdl.handle.net/1721.1/91497 https://orcid.org/0000-0003-4255-0492 |
Similar Items
-
Engineering of lipid-coated PLGA nanoparticles with a tunable payload of diagnostically active nanocrystals for medical imaging
by: Mieszawska, Aneta J., et al.
Published: (2013) -
Synthesis of Polymer–Lipid Nanoparticles for Image-Guided Delivery of Dual Modality Therapy
by: Mieszawska, Aneta J, et al.
Published: (2021) -
Single Step Reconstitution of Multifunctional High-Density Lipoprotein-Derived Nanomaterials Using Microfluidics
by: Kim, YongTae, et al.
Published: (2021) -
Mass Production and Size Control of Lipid–Polymer Hybrid Nanoparticles through Controlled Microvortices
by: Kim, YongTae, et al.
Published: (2014) -
Multifunctional Hyperelastic Structured Surface for Tunable and Switchable Transparency
by: Rayehe Karimi Mahabadi, et al.
Published: (2021-03-01)