Surface-Mediated Bone Tissue Morphogenesis from Tunable Nanolayered Implant Coatings
The functional success of a biomedical implant critically depends on its stable bonding with the host tissue. Aseptic implant loosening accounts for more than half of all joint replacement failures. Various materials, including metals and plastic, confer mechanical integrity to the device, but often...
| Principais autores: | , , , , , , , , |
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| Outros Autores: | |
| Formato: | Artigo |
| Idioma: | en_US |
| Publicado em: |
American Association for the Advancement of Science (AAAS)
2014
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| Acesso em linha: | http://hdl.handle.net/1721.1/91501 https://orcid.org/0000-0003-1727-5732 https://orcid.org/0000-0002-5568-6455 |
| _version_ | 1826205656074420224 |
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| author | Shah, Nisarg J. Hyder, Md Nasim Moskowitz, Joshua Seth Quadir, Mohiuddin Abdul Morton, Stephen Winford Seeherman, Howard J. Padera, Robert F. Spector, Myron Hammond, Paula T |
| author2 | Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies |
| author_facet | Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies Shah, Nisarg J. Hyder, Md Nasim Moskowitz, Joshua Seth Quadir, Mohiuddin Abdul Morton, Stephen Winford Seeherman, Howard J. Padera, Robert F. Spector, Myron Hammond, Paula T |
| author_sort | Shah, Nisarg J. |
| collection | MIT |
| description | The functional success of a biomedical implant critically depends on its stable bonding with the host tissue. Aseptic implant loosening accounts for more than half of all joint replacement failures. Various materials, including metals and plastic, confer mechanical integrity to the device, but often these materials are not suitable for direct integration with the host tissue, which leads to implant loosening and patient morbidity. We describe a self-assembled, osteogenic, polymer-based conformal coating that promotes stable mechanical fixation of an implant in a surrogate rodent model. A single modular, polymer-based multilayered coating was deposited using a water-based layer-by-layer approach, by which each element was introduced on the surface in nanoscale layers. Osteoconductive hydroxyapatite (HAP) and osteoinductive bone morphogenetic protein–2 (BMP-2) contained within the nanostructured coating acted synergistically to induce osteoblastic differentiation of endogenous progenitor cells within the bone marrow, without indications of a foreign body response. The tuned release of BMP-2, controlled by a hydrolytically degradable poly(β-amino ester), was essential for tissue regeneration, and in the presence of HAP, the modular coating encouraged the direct deposition of highly cohesive trabecular bone on the implant surface. In vivo, the bone-implant interfacial tensile strength was significantly higher than standard bioactive bone cement, did not fracture at the interface, and had long-term stability. Collectively, these results suggest that the multilayered coating system promotes biological fixation of orthopedic and dental implants to improve surgical outcomes by preventing loosening and premature failure. |
| first_indexed | 2024-09-23T13:16:32Z |
| format | Article |
| id | mit-1721.1/91501 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:16:32Z |
| publishDate | 2014 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | dspace |
| spelling | mit-1721.1/915012022-10-01T14:10:00Z Surface-Mediated Bone Tissue Morphogenesis from Tunable Nanolayered Implant Coatings Shah, Nisarg J. Hyder, Md Nasim Moskowitz, Joshua Seth Quadir, Mohiuddin Abdul Morton, Stephen Winford Seeherman, Howard J. Padera, Robert F. Spector, Myron Hammond, Paula T Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Chemical Engineering Massachusetts Institute of Technology. Laboratory for Manufacturing and Productivity Koch Institute for Integrative Cancer Research at MIT Shah, Nisarg J. Hyder, Md Nasim Moskowitz, Joshua Seth Quadir, Mohiuddin Abdul Morton, Stephen Winford Hammond, Paula T. The functional success of a biomedical implant critically depends on its stable bonding with the host tissue. Aseptic implant loosening accounts for more than half of all joint replacement failures. Various materials, including metals and plastic, confer mechanical integrity to the device, but often these materials are not suitable for direct integration with the host tissue, which leads to implant loosening and patient morbidity. We describe a self-assembled, osteogenic, polymer-based conformal coating that promotes stable mechanical fixation of an implant in a surrogate rodent model. A single modular, polymer-based multilayered coating was deposited using a water-based layer-by-layer approach, by which each element was introduced on the surface in nanoscale layers. Osteoconductive hydroxyapatite (HAP) and osteoinductive bone morphogenetic protein–2 (BMP-2) contained within the nanostructured coating acted synergistically to induce osteoblastic differentiation of endogenous progenitor cells within the bone marrow, without indications of a foreign body response. The tuned release of BMP-2, controlled by a hydrolytically degradable poly(β-amino ester), was essential for tissue regeneration, and in the presence of HAP, the modular coating encouraged the direct deposition of highly cohesive trabecular bone on the implant surface. In vivo, the bone-implant interfacial tensile strength was significantly higher than standard bioactive bone cement, did not fracture at the interface, and had long-term stability. Collectively, these results suggest that the multilayered coating system promotes biological fixation of orthopedic and dental implants to improve surgical outcomes by preventing loosening and premature failure. David H. Koch Institute for Integrative Cancer Research at MIT (Koch Institute Swanson Biotechnology Center) National Institutes of Health (U.S.) (NIH R01 AG029601) United States. Army Research Office. Institute for Soldier Nanotechnologies (contract no.W911NF-07-D-0004) David H. Koch Institute for Integrative Cancer Research at MIT (NCI grant P30 CA014051) Natural Sciences and Engineering Research Council of Canada (Fellowship) National Science Foundation (U.S.) (Fellowship) David H. Koch Institute for Integrative Cancer Research at MIT (David H. Koch (1962) Chair Professorship in Engineering) 2014-11-07T17:56:57Z 2014-11-07T17:56:57Z 2013-06 Article http://purl.org/eprint/type/JournalArticle 1946-6234 1946-6242 http://hdl.handle.net/1721.1/91501 Shah, N. J., M. N. Hyder, J. S. Moskowitz, M. A. Quadir, S. W. Morton, H. J. Seeherman, R. F. Padera, M. Spector, and P. T. Hammond. “Surface-Mediated Bone Tissue Morphogenesis from Tunable Nanolayered Implant Coatings.” Science Translational Medicine 5, no. 191 (June 26, 2013): 191ra83–191ra83. https://orcid.org/0000-0003-1727-5732 https://orcid.org/0000-0002-5568-6455 en_US http://dx.doi.org/10.1126/scitranslmed.3005576 Science Translational Medicine Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Association for the Advancement of Science (AAAS) PMC |
| spellingShingle | Shah, Nisarg J. Hyder, Md Nasim Moskowitz, Joshua Seth Quadir, Mohiuddin Abdul Morton, Stephen Winford Seeherman, Howard J. Padera, Robert F. Spector, Myron Hammond, Paula T Surface-Mediated Bone Tissue Morphogenesis from Tunable Nanolayered Implant Coatings |
| title | Surface-Mediated Bone Tissue Morphogenesis from Tunable Nanolayered Implant Coatings |
| title_full | Surface-Mediated Bone Tissue Morphogenesis from Tunable Nanolayered Implant Coatings |
| title_fullStr | Surface-Mediated Bone Tissue Morphogenesis from Tunable Nanolayered Implant Coatings |
| title_full_unstemmed | Surface-Mediated Bone Tissue Morphogenesis from Tunable Nanolayered Implant Coatings |
| title_short | Surface-Mediated Bone Tissue Morphogenesis from Tunable Nanolayered Implant Coatings |
| title_sort | surface mediated bone tissue morphogenesis from tunable nanolayered implant coatings |
| url | http://hdl.handle.net/1721.1/91501 https://orcid.org/0000-0003-1727-5732 https://orcid.org/0000-0002-5568-6455 |
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