Fabrication of a Hybrid Microfluidic System Incorporating both Lithographically Patterned Microchannels and a 3D Fiber-Formed Microfluidic Network
A device containing a 3D microchannel network (fabricated using sacrificial melt-spun microfibers) sandwiched between lithographically patterned microfluidic channels offers improved delivery of soluble compounds to a large volume compared to a simple stack of two microfluidic channel layers. With t...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Wiley-VCH Verlag GmbH & Co.
2014
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| Online Access: | http://hdl.handle.net/1721.1/91502 https://orcid.org/0000-0003-4255-0492 |
| _version_ | 1826214136547115008 |
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| author | Bellan, Leon M. Kniazeva, Tatiana Kim, Ernest S. Epshteyn, Alla A. Cropek, Donald M. Borenstein, Jeffrey T. Langer, Robert S |
| author2 | Charles Stark Draper Laboratory |
| author_facet | Charles Stark Draper Laboratory Bellan, Leon M. Kniazeva, Tatiana Kim, Ernest S. Epshteyn, Alla A. Cropek, Donald M. Borenstein, Jeffrey T. Langer, Robert S |
| author_sort | Bellan, Leon M. |
| collection | MIT |
| description | A device containing a 3D microchannel network (fabricated using sacrificial melt-spun microfibers) sandwiched between lithographically patterned microfluidic channels offers improved delivery of soluble compounds to a large volume compared to a simple stack of two microfluidic channel layers. With this improved delivery ability comes an increased fluidic resistance due to the tortuous network of small-diameter channels. |
| first_indexed | 2024-09-23T16:00:24Z |
| format | Article |
| id | mit-1721.1/91502 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:00:24Z |
| publishDate | 2014 |
| publisher | Wiley-VCH Verlag GmbH & Co. |
| record_format | dspace |
| spelling | mit-1721.1/915022022-09-29T17:37:49Z Fabrication of a Hybrid Microfluidic System Incorporating both Lithographically Patterned Microchannels and a 3D Fiber-Formed Microfluidic Network Bellan, Leon M. Kniazeva, Tatiana Kim, Ernest S. Epshteyn, Alla A. Cropek, Donald M. Borenstein, Jeffrey T. Langer, Robert S Charles Stark Draper Laboratory Massachusetts Institute of Technology. Center for Biomedical Engineering Koch Institute for Integrative Cancer Research at MIT Bellan, Leon M. Kniazeva, Tatiana Kim, Ernest S. Epshteyn, Alla A. Langer, Robert Borenstein, Jeffrey T. A device containing a 3D microchannel network (fabricated using sacrificial melt-spun microfibers) sandwiched between lithographically patterned microfluidic channels offers improved delivery of soluble compounds to a large volume compared to a simple stack of two microfluidic channel layers. With this improved delivery ability comes an increased fluidic resistance due to the tortuous network of small-diameter channels. United States. Army (Engineer Research and Development Center-Construction Engineering Research Laboratory (ERDC-CERL)) National Institutes of Health (U.S.) (NIH grant 5F32EB011866) National Institutes of Health (U.S.) (NIH Grant 1K99EB013630) National Institutes of Health (U.S.) (NIH NHLBI grant 1 R21 HL106585-01) National Heart, Lung, and Blood Institute (NIH NHLBI grant 1 R21 HL106585-01) 2014-11-07T18:20:54Z 2014-11-07T18:20:54Z 2012-03 2011-12 Article http://purl.org/eprint/type/JournalArticle 21922640 http://hdl.handle.net/1721.1/91502 Bellan, Leon M., Tatiana Kniazeva, Ernest S. Kim, Alla A. Epshteyn, Donald M. Cropek, Robert Langer, and Jeffrey T. Borenstein. “Fabrication of a Hybrid Microfluidic System Incorporating Both Lithographically Patterned Microchannels and a 3D Fiber-Formed Microfluidic Network.” Advanced Healthcare Materials 1, no. 2 (January 20, 2012): 164–167. https://orcid.org/0000-0003-4255-0492 en_US http://dx.doi.org/10.1002/adhm.201100052 Advanced Healthcare Materials Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wiley-VCH Verlag GmbH & Co. PMC |
| spellingShingle | Bellan, Leon M. Kniazeva, Tatiana Kim, Ernest S. Epshteyn, Alla A. Cropek, Donald M. Borenstein, Jeffrey T. Langer, Robert S Fabrication of a Hybrid Microfluidic System Incorporating both Lithographically Patterned Microchannels and a 3D Fiber-Formed Microfluidic Network |
| title | Fabrication of a Hybrid Microfluidic System Incorporating both Lithographically Patterned Microchannels and a 3D Fiber-Formed Microfluidic Network |
| title_full | Fabrication of a Hybrid Microfluidic System Incorporating both Lithographically Patterned Microchannels and a 3D Fiber-Formed Microfluidic Network |
| title_fullStr | Fabrication of a Hybrid Microfluidic System Incorporating both Lithographically Patterned Microchannels and a 3D Fiber-Formed Microfluidic Network |
| title_full_unstemmed | Fabrication of a Hybrid Microfluidic System Incorporating both Lithographically Patterned Microchannels and a 3D Fiber-Formed Microfluidic Network |
| title_short | Fabrication of a Hybrid Microfluidic System Incorporating both Lithographically Patterned Microchannels and a 3D Fiber-Formed Microfluidic Network |
| title_sort | fabrication of a hybrid microfluidic system incorporating both lithographically patterned microchannels and a 3d fiber formed microfluidic network |
| url | http://hdl.handle.net/1721.1/91502 https://orcid.org/0000-0003-4255-0492 |
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