Aberrant Development and Plasticity of Excitatory Visual Cortical Networks in the Absence of cpg15
During development, experience plays a crucial role in sculpting neuronal connections. Patterned neural activity guides formation of functional neural circuits through the selective stabilization of some synapses and the pruning of others. Activity-regulated factors are fundamental to this process,...
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| Format: | Article |
| Language: | en_US |
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Society for Neuroscience
2014
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| Online Access: | http://hdl.handle.net/1721.1/91516 https://orcid.org/0000-0002-1710-0767 |
| _version_ | 1826201716552368128 |
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| author | Picard, Nathalie Leslie, Jennifer H. Trowbridge, Sara Kishi Subramanian, Jaichandar Nedivi, Elly Fagiolini, Michela |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Picard, Nathalie Leslie, Jennifer H. Trowbridge, Sara Kishi Subramanian, Jaichandar Nedivi, Elly Fagiolini, Michela |
| author_sort | Picard, Nathalie |
| collection | MIT |
| description | During development, experience plays a crucial role in sculpting neuronal connections. Patterned neural activity guides formation of functional neural circuits through the selective stabilization of some synapses and the pruning of others. Activity-regulated factors are fundamental to this process, but their roles in synapse stabilization and maturation is still poorly understood. CPG15, encoded by the activity-regulated gene candidate plasticity gene 15, is a small, glycosylphosphatidylinositol (GPI)-linked, extracellular protein that promotes synapse stabilization. Here we show that global knock-out of cpg15 results in abnormal postnatal development of the excitatory network in visual cortex and an associated disruption in development of visual receptive field properties. In addition, whereas repeated stimulation induced potentiation and depression in wild-type mice, the depression was slower in cpg15 knock-out mice, suggesting impairment in short-term depression-like mechanisms. These findings establish the requirement for cpg15 in activity-dependent development of the visual system and demonstrate the importance of timely excitatory network development for normal visual function. |
| first_indexed | 2024-09-23T11:55:38Z |
| format | Article |
| id | mit-1721.1/91516 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:55:38Z |
| publishDate | 2014 |
| publisher | Society for Neuroscience |
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| spelling | mit-1721.1/915162022-09-27T22:53:54Z Aberrant Development and Plasticity of Excitatory Visual Cortical Networks in the Absence of cpg15 Picard, Nathalie Leslie, Jennifer H. Trowbridge, Sara Kishi Subramanian, Jaichandar Nedivi, Elly Fagiolini, Michela Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Leslie, Jennifer H. Trowbridge, Sara Kishi Subramanian, Jaichandar Nedivi, Elly During development, experience plays a crucial role in sculpting neuronal connections. Patterned neural activity guides formation of functional neural circuits through the selective stabilization of some synapses and the pruning of others. Activity-regulated factors are fundamental to this process, but their roles in synapse stabilization and maturation is still poorly understood. CPG15, encoded by the activity-regulated gene candidate plasticity gene 15, is a small, glycosylphosphatidylinositol (GPI)-linked, extracellular protein that promotes synapse stabilization. Here we show that global knock-out of cpg15 results in abnormal postnatal development of the excitatory network in visual cortex and an associated disruption in development of visual receptive field properties. In addition, whereas repeated stimulation induced potentiation and depression in wild-type mice, the depression was slower in cpg15 knock-out mice, suggesting impairment in short-term depression-like mechanisms. These findings establish the requirement for cpg15 in activity-dependent development of the visual system and demonstrate the importance of timely excitatory network development for normal visual function. National Eye Institute (Grant RO1 EY011894) National Institutes of Health (U.S.). Ruth L. Kirschstein National Research Service Award (Grant F31-NS0695) Harvard NeuroDiscovery Center. Harvard-MIT Joint Research Grants Program in Basic Neuroscience (Grant) 2014-11-12T12:59:44Z 2014-11-12T12:59:44Z 2014-03 2014-01 Article http://purl.org/eprint/type/JournalArticle 0270-6474 1529-2401 http://hdl.handle.net/1721.1/91516 Picard, N., J. H. Leslie, S. K. Trowbridge, J. Subramanian, E. Nedivi, and M. Fagiolini. “Aberrant Development and Plasticity of Excitatory Visual Cortical Networks in the Absence of Cpg15.” Journal of Neuroscience 34, no. 10 (March 5, 2014): 3517–3522. https://orcid.org/0000-0002-1710-0767 en_US http://dx.doi.org/10.1523/jneurosci.2955-13.2014 Journal of Neuroscience Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Society for Neuroscience Society for Neuroscience |
| spellingShingle | Picard, Nathalie Leslie, Jennifer H. Trowbridge, Sara Kishi Subramanian, Jaichandar Nedivi, Elly Fagiolini, Michela Aberrant Development and Plasticity of Excitatory Visual Cortical Networks in the Absence of cpg15 |
| title | Aberrant Development and Plasticity of Excitatory Visual Cortical Networks in the Absence of cpg15 |
| title_full | Aberrant Development and Plasticity of Excitatory Visual Cortical Networks in the Absence of cpg15 |
| title_fullStr | Aberrant Development and Plasticity of Excitatory Visual Cortical Networks in the Absence of cpg15 |
| title_full_unstemmed | Aberrant Development and Plasticity of Excitatory Visual Cortical Networks in the Absence of cpg15 |
| title_short | Aberrant Development and Plasticity of Excitatory Visual Cortical Networks in the Absence of cpg15 |
| title_sort | aberrant development and plasticity of excitatory visual cortical networks in the absence of cpg15 |
| url | http://hdl.handle.net/1721.1/91516 https://orcid.org/0000-0002-1710-0767 |
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