The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

Reprogramming of cellular metabolism is a key event during tumorigenesis. Despite being known for decades (Warburg effect), the molecular mechanisms regulating this switch remained unexplored. Here, we identify SIRT6 as a tumor suppressor that regulates aerobic glycolysis in cancer cells. Importantl...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों: Zwaans, Bernadette M.M., Silberman, Dafne M., Goren, Alon, Zhong, Lei, Ram, Oren, Truelove, Jessica, Guimaraes, Alexander R., Toiber, Debra, Cosentino, Claudia, Greenson, Joel K., MacDonald, Alasdair I., McGlynn, Liane, Maxwell, Fraser, Edwards, Joanne, Giacosa, Sofia, Guccione, Ernesto, Weissleder, Ralph, Bernstein, Bradley E., Regev, Aviv, Shiels, Paul G., Lombard, David B., Mostoslavsky, Raul, Sebastian, Carlos, Gymrek, Melissa A.
अन्य लेखक: Harvard University--MIT Division of Health Sciences and Technology
स्वरूप: लेख
भाषा:en_US
प्रकाशित: Elsevier 2014
ऑनलाइन पहुंच:http://hdl.handle.net/1721.1/91526
https://orcid.org/0000-0001-8567-2049
https://orcid.org/0000-0002-6086-3903

इंटरनेट

http://hdl.handle.net/1721.1/91526
https://orcid.org/0000-0001-8567-2049
https://orcid.org/0000-0002-6086-3903

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