The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

Reprogramming of cellular metabolism is a key event during tumorigenesis. Despite being known for decades (Warburg effect), the molecular mechanisms regulating this switch remained unexplored. Here, we identify SIRT6 as a tumor suppressor that regulates aerobic glycolysis in cancer cells. Importantl...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Zwaans, Bernadette M.M., Silberman, Dafne M., Goren, Alon, Zhong, Lei, Ram, Oren, Truelove, Jessica, Guimaraes, Alexander R., Toiber, Debra, Cosentino, Claudia, Greenson, Joel K., MacDonald, Alasdair I., McGlynn, Liane, Maxwell, Fraser, Edwards, Joanne, Giacosa, Sofia, Guccione, Ernesto, Weissleder, Ralph, Bernstein, Bradley E., Regev, Aviv, Shiels, Paul G., Lombard, David B., Mostoslavsky, Raul, Sebastian, Carlos, Gymrek, Melissa A.
مؤلفون آخرون: Harvard University--MIT Division of Health Sciences and Technology
التنسيق: مقال
اللغة:en_US
منشور في: Elsevier 2014
الوصول للمادة أونلاين:http://hdl.handle.net/1721.1/91526
https://orcid.org/0000-0001-8567-2049
https://orcid.org/0000-0002-6086-3903

الانترنت

http://hdl.handle.net/1721.1/91526
https://orcid.org/0000-0001-8567-2049
https://orcid.org/0000-0002-6086-3903

مواد مشابهة