The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

Reprogramming of cellular metabolism is a key event during tumorigenesis. Despite being known for decades (Warburg effect), the molecular mechanisms regulating this switch remained unexplored. Here, we identify SIRT6 as a tumor suppressor that regulates aerobic glycolysis in cancer cells. Importantl...

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Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Zwaans, Bernadette M.M., Silberman, Dafne M., Goren, Alon, Zhong, Lei, Ram, Oren, Truelove, Jessica, Guimaraes, Alexander R., Toiber, Debra, Cosentino, Claudia, Greenson, Joel K., MacDonald, Alasdair I., McGlynn, Liane, Maxwell, Fraser, Edwards, Joanne, Giacosa, Sofia, Guccione, Ernesto, Weissleder, Ralph, Bernstein, Bradley E., Regev, Aviv, Shiels, Paul G., Lombard, David B., Mostoslavsky, Raul, Sebastian, Carlos, Gymrek, Melissa A.
Άλλοι συγγραφείς: Harvard University--MIT Division of Health Sciences and Technology
Μορφή: Άρθρο
Γλώσσα:en_US
Έκδοση: Elsevier 2014
Διαθέσιμο Online:http://hdl.handle.net/1721.1/91526
https://orcid.org/0000-0001-8567-2049
https://orcid.org/0000-0002-6086-3903

Διαδίκτυο

http://hdl.handle.net/1721.1/91526
https://orcid.org/0000-0001-8567-2049
https://orcid.org/0000-0002-6086-3903

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