The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

Reprogramming of cellular metabolism is a key event during tumorigenesis. Despite being known for decades (Warburg effect), the molecular mechanisms regulating this switch remained unexplored. Here, we identify SIRT6 as a tumor suppressor that regulates aerobic glycolysis in cancer cells. Importantl...

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Bibliografske podrobnosti
Main Authors: Zwaans, Bernadette M.M., Silberman, Dafne M., Goren, Alon, Zhong, Lei, Ram, Oren, Truelove, Jessica, Guimaraes, Alexander R., Toiber, Debra, Cosentino, Claudia, Greenson, Joel K., MacDonald, Alasdair I., McGlynn, Liane, Maxwell, Fraser, Edwards, Joanne, Giacosa, Sofia, Guccione, Ernesto, Weissleder, Ralph, Bernstein, Bradley E., Regev, Aviv, Shiels, Paul G., Lombard, David B., Mostoslavsky, Raul, Sebastian, Carlos, Gymrek, Melissa A.
Drugi avtorji: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Jezik:en_US
Izdano: Elsevier 2014
Online dostop:http://hdl.handle.net/1721.1/91526
https://orcid.org/0000-0001-8567-2049
https://orcid.org/0000-0002-6086-3903

Internet

http://hdl.handle.net/1721.1/91526
https://orcid.org/0000-0001-8567-2049
https://orcid.org/0000-0002-6086-3903

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