p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer
Anaplastic thyroid carcinoma (ATC) has among the worst prognoses of any solid malignancy. The low incidence of the disease has in part precluded systematic clinical trials and tissue collection, and there has been little progress in developing effective therapies. v-raf murine sarcoma viral oncogene...
Main Authors: | McFadden, David Glenn, Vernon, Amanda, Santiago, Philip M., Martinez-McFaline, Raul, Crowley, Denise M., McMahon, Martin, Sadow, Peter M., Bhutkar, Arjun, Jacks, Tyler E |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology |
Format: | Article |
Language: | en_US |
Published: |
National Academy of Sciences (U.S.)
2014
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Online Access: | http://hdl.handle.net/1721.1/91529 https://orcid.org/0000-0001-5785-8911 https://orcid.org/0000-0003-4336-2135 |
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