Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

HSP90 is a molecular chaperone that associates with numerous substrate proteins called clients. It plays many important roles in human biology and medicine, but determinants of client recognition by HSP90 have remained frustratingly elusive. We systematically and quantitatively surveyed most human k...

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Bibliographic Details
Main Authors:	Taipale, Mikko, Krykbaeva, Irina, Kayatekin, Can, Westover, Kenneth D., Karras, Georgios I., Lindquist, Susan, Koeva, Martina I
Other Authors:	Massachusetts Institute of Technology. Department of Biological Engineering
Format:	Article
Language:	en_US
Published:	Elsevier 2014
Online Access:	http://hdl.handle.net/1721.1/91538 https://orcid.org/0000-0003-1307-882X https://orcid.org/0000-0001-7024-0921

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