Pervasive Synaptic Branch Removal in the Mammalian Neuromuscular System at Birth

Pervasive Synaptic Branch Removal in the Mammalian Neuromuscular System at Birth

Using light and serial electron microscopy, we show profound refinements in motor axonal branching and synaptic connectivity before and after birth. Embryonic axons become maximally connected just before birth when they innervate ~10-fold more muscle fibers than in maturity. In some developing muscl...

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Bibliographic Details
Main Authors: Tapia, Juan C., Wylie, John D., Kasthuri, Narayanan, Hayworth, Kenneth J., Schalek, Richard, Berger, Daniel R., Guatimosim, Cristina, Seung, H. Sebastian, Lichtman, Jeff W.
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:en_US
Published: Elsevier 2014
Online Access:http://hdl.handle.net/1721.1/91553

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